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Term:membranoproliferative glomerulonephritis
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Accession:DOID:2920 term browser browse the term
Definition:Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Synonyms:exact_synonym: DDD MPGNII;   Dense Deposit Disease;   Hypocomplementemic Glomerulonephritides;   Hypocomplementemic Glomerulonephritis;   Lobular glomerulonephritis;   MPGN;   MPGNII;   Membranoproliferative Glomerulonephritides;   Membranoproliferative Glomerulonephritis Type II;   Membranoproliferative Glomerulonephritis, Type I;   Membranoproliferative Glomerulonephritis, Type III;   Mesangiocapillary Glomerulonephritides;   Mesangiocapillary Glomerulonephritis;   Mesangiocapillary Glomerulonephritis, Type I;   Mesangiocapillary Glomerulonephritis, Type II;   Subendothelial Membranoproliferative Glomerulonephritis;   Type II MPGN;   chronic glomerulonephritis, lobular
 primary_id: MESH:D015432;   RDO:0002519
 xref: GARD:11982
For additional species annotation, visit the Alliance of Genome Resources.


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membranoproliferative glomerulonephritis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11554173
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:2314193
RGD:2314222
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:11554173
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:8549648
G Ccr6 C-C motif chemokine receptor 6 JBrowse link 1 53,063,380 53,087,519 RGD:7483632
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:2293563
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 4 168,689,043 168,694,159 RGD:2293620
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:734771
RGD:7242760
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:11554173
RGD:8554872
G Cfi complement factor I JBrowse link 2 235,264,149 235,305,779 RGD:6906892
G Ctgf connective tissue growth factor JBrowse link 1 21,851,657 21,854,773 RGD:1601118
G Cxcr1 C-X-C motif chemokine receptor 1 JBrowse link 9 81,466,430 81,469,299 RGD:7207859
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:4144848
RGD:8662296
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:9588308
G F5 coagulation factor V JBrowse link 13 82,479,997 82,535,540 RGD:1601118
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:7206847
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7175308
G Myoc myocilin JBrowse link 13 80,517,531 80,527,928 RGD:7401266
G Pfn1 profilin 1 JBrowse link 10 57,273,003 57,275,708 RGD:729497
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11554173
G Prf1 perforin 1 JBrowse link 20 30,915,294 30,920,804 RGD:1599935
G Sparc secreted protein acidic and cysteine rich JBrowse link 10 40,742,390 40,764,232 RGD:2300070
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:1601601
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:7246909
G Tlr11 toll-like receptor 11 JBrowse link 15 27,177,900 27,182,339 RGD:7246909
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:7246909
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7246909
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:7246909
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:7246909
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:7246909
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:7246909
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:7246909
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:11554173
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:7364995
Glomerulonephritis with Sparse Hair and Telangiectases term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sox18 SRY box 18 JBrowse link 3 177,177,237 177,179,039 RGD:8554872
RGD:7240710
G Tcea2 transcription elongation factor A2 JBrowse link 3 177,187,686 177,195,898 RGD:8554872
Glomerulopathy with Giant Fibrillar Deposits term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:7240710
RGD:8554872
Nephrotic Syndrome, Type 7 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgke diacylglycerol kinase epsilon JBrowse link 10 76,375,981 76,408,224 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14042
    disease of anatomical entity 13255
      immune system disease 2381
        membranoproliferative glomerulonephritis 39
          CFHR5 Deficiency 0
          Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
          Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
          Glomerulonephritis with Sparse Hair and Telangiectases 2
          Glomerulopathy with Giant Fibrillar Deposits 1
          MPGN II with Complement Factor H Deficiency 0
          Membranoproliferative Glomerulonephritis, X-Linked 0
          Nephrotic Syndrome, Type 7 1
Path 2
Term Annotations click to browse term
  disease 14042
    disease of anatomical entity 13255
      Urogenital Diseases 3651
        urinary system disease 1895
          kidney disease 1697
            nephritis 411
              glomerulonephritis 359
                mesangial proliferative glomerulonephritis 47
                  Chronic Mesangial Proliferative Glomerulonephritis 41
                    membranoproliferative glomerulonephritis 39
                      CFHR5 Deficiency 0
                      Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
                      Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
                      Glomerulonephritis with Sparse Hair and Telangiectases 2
                      Glomerulopathy with Giant Fibrillar Deposits 1
                      MPGN II with Complement Factor H Deficiency 0
                      Membranoproliferative Glomerulonephritis, X-Linked 0
                      Nephrotic Syndrome, Type 7 1
paths to the root