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ONTOLOGY REPORT - ANNOTATIONS


Term:nalidixic acid
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Accession:CHEBI:100147 term browser browse the term
Definition:A monocarboxylic acid comprising 1,8-naphthyridin-4-one substituted by carboxylic acid, ethyl and methyl groups at positions 3, 1, and 7, respectively. An orally administered antibacterial, it is used in the treatment of lower urinary-tract infections due to Gram-negative bacteria, including the majority of E. coli, Enterobacter, Klebsiella, and Proteus species.
Synonyms:related_synonym: 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;   1-Aethyl-7-methyl-1,8-naphthyridin-4-on-3-karbonsaeure;   1-ethyl-7-methyl-1,4-dihydro-1,8-naphthyridin-4-one-3-carboxylic acid;   3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one;   Formula=C12H12N2O3;   InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17);   InChIKey=MHWLWQUZZRMNGJ-UHFFFAOYSA-N;   SMILES=CCn1cc(C(O)=O)c(=O)c2ccc(C)nc12;   acide nalidixique;   acido nalidixico;   acidum nalidixicum
 alt_id: CHEBI:7456
 xref: CAS:389-08-2 "ChemIDplus";   CAS:389-08-2 "KEGG COMPOUND";   DrugBank:DB00779;   Drug_Central:1875 "DrugCentral";   KEGG:C05079;   KEGG:D00183;   LINCS:LSM-5590
 xref_mesh: MESH:D009268
 xref: PDBeChem:NIX;   PMID:11321869 "Europe PMC";   PMID:12002106 "Europe PMC";   PMID:12399485 "Europe PMC";   PMID:12702698 "Europe PMC";   PMID:14107587 "Europe PMC";   PMID:16107187 "Europe PMC";   PMID:16423473 "Europe PMC";   PMID:16667857 "Europe PMC";   PMID:16803589 "Europe PMC";   PMID:17132068 "Europe PMC";   PMID:17631104 "Europe PMC";   PMID:18788798 "Europe PMC";   PMID:19071706 "Europe PMC";   PMID:28166217 "Europe PMC";   Patent:BE612258;   Patent:US3590036;   Reaxys:750515 "Reaxys";   VSDB:1880;   Wikipedia:Nalidixic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:62070


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nalidixic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Mmp13 matrix metallopeptidase 13 JBrowse link 8 5,522,739 5,533,018 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        antimicrobial agent 17211
          nalidixic acid 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteropolycyclic compound 17570
                                    organic heterobicyclic compound 16240
                                      mancude organic heterobicyclic parent 5176
                                        naphthyridine 761
                                          1,8-naphthyridine 381
                                            1,8-naphthyridine derivative 381
                                              nalidixic acid 2
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