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Accession:CHEBI:10023 term browser browse the term
Definition:A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
Synonyms:exact_synonym: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
 related_synonym: (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol;   Formula=C16H14F3N5O;   InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1;   InChIKey=BCEHBSKCWLPMDN-MGPLVRAMSA-N;   SMILES=C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F;   VCZ;   Vfend;   voriconazol;   voriconazolum
 alt_id: CHEBI:127308
 xref: Beilstein:7694998 "Beilstein";   CAS:137234-62-9 "ChemIDplus";   CAS:137234-62-9 "DrugBank";   CAS:137234-62-9 "KEGG COMPOUND";   CAS:137234-62-9 "KEGG DRUG";   DrugBank:DB00582;   Drug_Central:2846 "DrugCentral";   KEGG:C07622;   KEGG:D00578;   LINCS:LSM-5244
 xref_mesh: MESH:D065819
 xref: PMID:12940129 "Europe PMC";   PMID:22718362 "Europe PMC";   PMID:23392902 "Europe PMC";   PMID:23527908 "Europe PMC";   PMID:23766489 "Europe PMC";   PMID:24102553 "Europe PMC";   Patent:EP440372;   Patent:US5278175;   Wikipedia:Voriconazole

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voriconazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        antimicrobial agent 17211
          antifungal agent 14774
            conazole antifungal agent 2871
              conazole antifungal drug 780
                voriconazole 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  heteroarene 15814
                                    monocyclic heteroarene 13126
                                      azole 12255
                                        triazoles 3606
                                          triazole antifungal agent 2354
                                            triazole antifungal drug 57
                                              voriconazole 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.