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Accession:CHEBI:100246 term browser browse the term
Definition:A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.
Synonyms:exact_synonym: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid;   1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure;   Formula=C16H18FN3O3;   InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23);   InChIKey=OGJPXUAPXNRGGI-UHFFFAOYSA-N;   NFLX;   SMILES=CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N1CCNCC1;   norfloxacine;   norfloxacino;   norfloxacinum
 alt_id: CHEBI:7629
 xref: Beilstein:567897 "Beilstein";   CAS:70458-96-7 "ChemIDplus";   CAS:70458-96-7 "KEGG COMPOUND";   DrugBank:DB01059;   Drug_Central:1967 "DrugCentral";   Gmelin:1576626 "Gmelin";   HMDB:HMDB0015192;   KEGG:C06687;   KEGG:D00210;   LINCS:LSM-5286
 xref_mesh: MESH:D009643
 xref: PMID:3317294 "Europe PMC";   PMID:3908074 "Europe PMC";   PMID:6211142 "Europe PMC";   PMID:6224685 "Europe PMC";   PMID:6234465 "Europe PMC";   PMID:6454381 "Europe PMC";   PMID:6461606 "Europe PMC";   Patent:BE863429;   Patent:DE2840910;   Patent:US4146719;   Patent:US4292317;   Reaxys:567897 "Reaxys";   VSDB:1831;   Wikipedia:Norfloxacin

show annotations for term's descendants       view all columns           Sort by:
norfloxacin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Mmp13 matrix metallopeptidase 13 JBrowse link 8 5,522,739 5,533,018 RGD:6480464
G Mr1 major histocompatibility complex, class I-related JBrowse link 13 72,771,992 72,789,861 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        xenobiotic 18261
          norfloxacin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        aromatic carboxylic acid 10745
                                          quinolinemonocarboxylic acid 89
                                            norfloxacin 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.