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Accession:CHEBI:10112 term browser browse the term
Definition:A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
Synonyms:exact_synonym: 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
 related_synonym: (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea;   Formula=C11H12N2O2S;   InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14);   InChIKey=MWLSOWXNZPKENC-UHFFFAOYSA-N;   Leutrol;   N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea;   N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea;   SMILES=CC(N(O)C(N)=O)c1cc2ccccc2s1;   Zyflo;   zileutonum
 xref: CAS:111406-87-2 "ChemIDplus";   CAS:111406-87-2 "KEGG DRUG";   DrugBank:DB00744;   Drug_Central:2862 "DrugCentral";   KEGG:D00414;   LINCS:LSM-5084
 xref_mesh: MESH:C063449
 xref: PMID:19309543 "Europe PMC";   PMID:19645854 "Europe PMC";   PMID:20204486 "Europe PMC";   PMID:20436887 "Europe PMC";   Reaxys:4869674 "Reaxys";   Wikipedia:Zileuton

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zileuton term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALOX5 arachidonate 5-lipoxygenase JBrowse link 28 2,170,920 2,218,765 RGD:6480464

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  CHEBI ontology 223
    role 223
      application 188
        anti-asthmatic agent 4
          anti-asthmatic drug 4
            zileuton 1
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Term Annotations click to browse term
  CHEBI ontology 223
    subatomic particle 223
      composite particle 223
        hadron 223
          baryon 223
            nucleon 223
              atomic nucleus 223
                atom 223
                  main group element atom 216
                    p-block element atom 216
                      carbon group element atom 205
                        carbon atom 204
                          organic molecular entity 204
                            organic group 153
                              organic divalent group 152
                                organodiyl group 152
                                  carbonyl group 152
                                    carbonyl compound 152
                                      carboxylic acid 112
                                        carboacyl group 47
                                          univalent carboacyl group 47
                                            carbamoyl group 44
                                              carboxamide 44
                                                monocarboxylic acid amide 19
                                                  urea 9
                                                    ureas 7
                                                      zileuton 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.