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ONTOLOGY REPORT - ANNOTATIONS


Term:aloxistatin
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Accession:CHEBI:101381 term browser browse the term
Definition:An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylbutyl)-L-leucinamide.
Synonyms:exact_synonym: ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate
 related_synonym: E 64d;   E64d;   Ethyl (+)-(2S,3S)-2,3-epoxy-N-((S)-1-(isopentylcarbamoyl)-3-methylbutyl)succinamate;   Formula=C17H30N2O5;   InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1;   InChIKey=SRVFFFJZQVENJC-IHRRRGAJSA-N;   Loxistatin;   SMILES=O1[C@@H]([C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C)C(=O)OCC;   aloxistatina;   aloxistatine;   aloxistatinum
 xref: Beilstein:5354546;   CAS:88321-09-9
 xref_mesh: MESH:C108192
 xref: PMID:26388830;   Reaxys:5354546


show annotations for term's descendants       view all columns           Sort by:
 
aloxistatin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Capn1 calpain 1 JBrowse link 1 221,346,081 221,370,965 RGD:6480464
G Capn7 calpain 7 JBrowse link 16 7,435,541 7,472,483 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Ctsd cathepsin D JBrowse link 1 215,541,570 215,553,446 RGD:6480464
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:6480464
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      biological role 19737
        antimicrobial agent 17320
          antiviral agent 10233
            anticoronaviral agent 8939
              aloxistatin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18034
                                        amino acid 12477
                                          alpha-amino acid 7712
                                            L-alpha-amino acid 7383
                                              pyruvate family amino acid 242
                                                L-leucine 85
                                                  L-leucine derivative 79
                                                    aloxistatin 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.