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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfamethazine
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Accession:CHEBI:102265 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:related_synonym: (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin;   2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-Sulfanilamido-4,6-dimethylpyrimidine;   4,6-Dimethyl-2-sulfanilamidopyrimidine;   4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide;   4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide;   4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide;   6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin;   Formula=C12H14N4O2S;   InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16);   InChIKey=ASWVTGNCAZCNNR-UHFFFAOYSA-N;   N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide;   N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   SMILES=Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1;   SMZ;   Sulfadimethyldiazine;   Sulfadimethylpyrimidine;   Sulfametazina;   Sulfametazyny;   Sulfamezathine;   Sulphadimethylpyrimidine;   Sulphamethazine;   sulfadimidina;   sulfadimidine;   sulfadimidinum;   sulfamethazone
 xref: Beilstein:261304;   CAS:57-68-1;   DrugBank:DB01582;   Drug_Central:2502;   Gmelin:1009759;   HMDB:HMDB0015522;   KEGG:C19530;   KEGG:D02436;   LINCS:LSM-5295
 xref_mesh: MESH:D013418
 xref: PMID:11431418;   PMID:14552772;   PMID:15603963;   PMID:17311370;   PMID:17596632;   PMID:20028131;   PMID:22903812;   PMID:23218311;   PMID:23384282;   PMID:23434485;   PMID:23454458;   PMID:23562141;   PMID:23636590;   PMID:23673752;   PMID:23673946;   PMID:23704574;   PMID:6864729;   PMID:7021831;   PMID:7328159;   PMID:8199304;   PMID:9886437;   Patent:EP1861101;   Patent:GB546158;   Patent:GB552887;   Patent:US2407966;   Patent:US3119818;   Patent:WO2005016386;   Reaxys:261304;   VSDB:1829;   Wikipedia:Sulfadimidine


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sulfamethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation
increases metabolic processing
ISO NAT2 protein results in increased acetylation of Sulfamethazine
NAT2 polymorphism affects the acetylation of Sulfamethazine
NAT2 protein results in increased metabolism of Sulfamethazine
CTD PMID:12222688, PMID:15627487, PMID:15880531, PMID:21317369, PMID:28516247, PMID:30358977 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
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G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Sulfamethazine results in increased activity of NR1I2 protein CTD PMID:12065438 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          sulfamethazine 2
            sulfabromomethazine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        aromatic amine 13618
                                          anilines 12329
                                            substituted aniline 11825
                                              sulfanilamide 245
                                                sulfamethazine 2
                                                  sulfabromomethazine 0
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