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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metoclopramide
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Accession:CHEBI:107736 term browser browse the term
Definition:A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Synonyms:related_synonym: 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide;   2-methoxy-5-chloroprocainamide;   4-amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide;   4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide;   4-amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide;   Elieten;   Formula=C14H22ClN3O2;   InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19);   InChIKey=TTWJBBZEZQICBI-UHFFFAOYSA-N;   Reliveran;   SMILES=CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC;   metoclopramida;   metoclopramidum
 alt_id: CHEBI:6898
 xref: CAS:364-62-5;   DrugBank:DB01233;   Drug_Central:1782;   HMDB:HMDB0015363;   KEGG:C07868;   KEGG:D00726;   LINCS:LSM-3689
 xref_mesh: MESH:D008787
 xref: Patent:BE620543;   Patent:US3177252;   Reaxys:1884366;   VSDB:1821;   Wikipedia:Metoclopramide
 cyclic_relationship: is_conjugate_base_of CHEBI:61170


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metoclopramide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Metoclopramide CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Metoclopramide binds to and results in decreased activity of ACHE protein; Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [mipafox results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; Metoclopramide inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] CTD PMID:12518340, PMID:14635269, PMID:15052610, PMID:16193528 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Metoclopramide results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Amy1a amylase, alpha 1A multiple interactions EXP Metoclopramide inhibits the reaction [Apomorphine results in increased secretion of and results in increased activity of AMY1A protein] CTD PMID:21173550 NCBI chr 2:216,428,709...216,443,518
Ensembl chr 2:216,428,709...216,443,518
JBrowse link
G Ar androgen receptor affects expression
multiple interactions
increases expression
EXP Metoclopramide affects the expression of AR protein
[Metoclopramide results in decreased abundance of Testosterone] which results in decreased expression of AR protein
Metoclopramide results in increased expression of AR protein
CTD PMID:14655152, PMID:16529173, PMID:16584088 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Avp arginine vasopressin multiple interactions ISO Metoclopramide inhibits the reaction [Apomorphine results in increased expression of AVP protein] CTD PMID:16575035 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Metoclopramide inhibits the reaction [mipafox binds to and results in decreased activity of BCHE protein]; Metoclopramide inhibits the reaction [Paraoxon binds to and results in decreased activity of BCHE protein] CTD PMID:12518340, PMID:15052610 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Metoclopramide inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased activity of and results in increased cleavage of CASP3 protein]; Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding
EXP [Metoclopramide binds to and results in decreased activity of CHRM3 protein] which results in decreased susceptibility to Carbachol; Metoclopramide inhibits the reaction [4-diphenylacetoxy-N-methylpiperidine methobromide binds to CHRM3 protein]
Metoclopramide binds to CHRM3 protein
CTD PMID:15105209 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL2 mRNA] CTD PMID:21691039 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA] CTD PMID:21691039 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 gene polymorphism affects the metabolism of Metoclopramide CTD PMID:16702617 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects binding
increases expression
ISO
EXP
Metoclopramide binds to and results in decreased activity of DRD2 protein
Metoclopramide binds to DRD2 protein
Metoclopramide results in increased expression of DRD2 protein
CTD PMID:1930352, PMID:9808703, PMID:11561213, PMID:12130853, PMID:12593651, PMID:17201744, PMID:17303669, PMID:18457824, PMID:21175574 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [Metoclopramide co-treated with Estradiol] results in decreased expression of ESR1 protein CTD PMID:11786374 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gcg glucagon increases secretion ISO Metoclopramide results in increased secretion of GCG protein CTD PMID:20829521 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gip gastric inhibitory polypeptide increases secretion ISO Metoclopramide results in increased secretion of GIP protein CTD PMID:20829521 NCBI chr10:83,835,080...83,848,399
Ensembl chr10:83,840,303...83,848,396
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
affects binding
decreases activity
ISO
EXP
[Dexamethasone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; Metoclopramide binds to and results in decreased activity of HTR3A protein; Metoclopramide inhibits the reaction [GR 65630 binds to HTR3A protein]
Metoclopramide binds to HTR3A protein
Metoclopramide results in decreased activity of HTR3A protein
CTD PMID:12130853, PMID:12593651, PMID:15329590, PMID:16041395, PMID:17201744 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression
ISO Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Metoclopramide results in decreased activity of KCNH2 protein CTD PMID:15640612 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression ISO Metoclopramide results in increased expression of LHB protein CTD PMID:2880862 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:21691039 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Metoclopramide inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:21691039 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]; Metoclopramide inhibits the reaction [Paraoxon results in increased cleavage of PARP1 protein] CTD PMID:29027213 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prl prolactin multiple interactions
increases expression
increases secretion
affects expression
ISO
EXP
Lisuride inhibits the reaction [Metoclopramide results in increased secretion of PRL protein]; Metoclopramide results in increased expression of and results in increased secretion of PRL protein
Metoclopramide results in increased expression of PRL protein
Metoclopramide affects the expression of PRL protein
CTD PMID:386688, PMID:1304515, PMID:1304992, PMID:2635674, PMID:3962302, PMID:7270091, PMID:8803308, PMID:9352036, PMID:11561213, PMID:11786374, PMID:12056626, PMID:14655152, PMID:14870917, PMID:16529173, PMID:16584088, PMID:16815880, PMID:17187127, PMID:17303669, PMID:18978642, PMID:19838586, PMID:20530986 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prlr prolactin receptor increases expression ISO Metoclopramide results in increased expression of PRLR mRNA; Metoclopramide results in increased expression of PRLR mRNA alternative form CTD PMID:19304288 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Metoclopramide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression EXP Metoclopramide results in increased expression of SRD5A1 mRNA CTD PMID:18978642 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression EXP Metoclopramide results in increased expression of SRD5A2 mRNA CTD PMID:18978642 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Metoclopramide inhibits the reaction [TNF protein results in increased activity of CASP3 protein] CTD PMID:29027213 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
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  CHEBI ontology 19810
    role 19758
      biological role 19758
        xenobiotic 18408
          metoclopramide 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  arenecarboxamide 6512
                                                    benzamides 6512
                                                      metoclopramide 30
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