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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-methoxyestrone
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Accession:CHEBI:1189 term browser browse the term
Definition:A 17-oxo steroid that is estrone in which the hydrogen at position 2 has been replaced by a methoxy group.
Synonyms:related_synonym: 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one;   Formula=C19H24O3;   InChI=1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1;   InChIKey=WHEUWNKSCXYKBU-QPWUGHHJSA-N;   SMILES=[H][C@]12CC[C@]3(C)C(=O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)c(OC)cc21
 xref: CAS:362-08-3;   KEGG:C05299;   LIPID_MAPS_instance:LMST02010033
 xref_mesh: MESH:C003655
 xref: PMID:14577664;   PMID:21488127


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2-methoxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone CTD PMID:16397246 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              estrone 125
                2-methoxyestrone 1
                  2-methoxyestrone 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxo steroid 9276
                                          17-oxo steroid 257
                                            estrone 125
                                              2-methoxyestrone 1
                                                2-methoxyestrone 3-O-(beta-D-glucuronide) 0
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