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Accession:CHEBI:119573 term browser browse the term
Definition:The amide resulting from the formal condensation of 5-[(methylsulfonyl)amino]-1H-indole-2-carboxylic acid and 4-amino group of 1-[3-(isopropylamino)pyridin-2-yl]piperazine, delavirdine is a non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. Viral resistance emerges rapidly when delavirdine is used alone, so it is therefore used (as the methanesulfonic acid salt) with other antiretrovirals for combination therapy of HIV infection.
Synonyms:exact_synonym: N-[2-({4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide
 related_synonym: (N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide);   1-(3-((1-methylethyl)amino)-2-pyridinyl)-4-((5-((methylsulfonyl)amino)-1H-indol-2-yl)carbonyl)piperazine;   2-(4-(5-methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine;   Formula=C22H28N6O3S;   InChI=1S/C22H28N6O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20/h4-8,13-15,24-26H,9-12H2,1-3H3;   InChIKey=WHBIGIKBNXZKFE-UHFFFAOYSA-N;   N-(2-(1-(3-(isopropylamino)pyridin-2-yl)piperazine-4-carbonyl)-1H-indol-5-yl)methanesulfonamide;   SMILES=CC(C)Nc1cccnc1N1CCN(CC1)C(=O)c1cc2cc(NS(C)(=O)=O)ccc2[nH]1
 alt_id: CHEBI:4378;   CHEBI:45727
 xref: Beilstein:6356813 "Beilstein";   CAS:136817-59-9 "ChemIDplus";   CAS:136817-59-9 "KEGG COMPOUND";   DrugBank:DB00705;   Drug_Central:799 "DrugCentral";   KEGG:C06941;   KEGG:D07782
 xref_mesh: MESH:D020008
 xref: PDBeChem:SPP;   PMID:11124228 "Europe PMC";   PMID:11225565 "Europe PMC";   PMID:11327199 "Europe PMC";   PMID:11363651 "Europe PMC";   PMID:11363709 "Europe PMC";   PMID:11364022 "Europe PMC";   PMID:11364099 "Europe PMC";   PMID:11364363 "Europe PMC";   PMID:11364481 "Europe PMC";   PMID:11590527 "Europe PMC";   PMID:16449090 "Europe PMC";   PMID:21080015 "Europe PMC";   PMID:21683601 "Europe PMC";   PMID:21865017 "Europe PMC";   Patent:WO9109849;   Reaxys:6356813 "Reaxys";   Wikipedia:Delavirdine

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delavirdine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        antimicrobial agent 17211
          antiviral agent 3709
            antiviral drug 1776
              delavirdine 1
                delavirdine mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  indolecarboxamide 4
                                                    delavirdine 1
                                                      delavirdine mesylate 0
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