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ONTOLOGY REPORT - ANNOTATIONS


Term:3-bromopyruvic acid
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Accession:CHEBI:131461 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug
Synonyms:exact_synonym: 3-bromo-2-oxopropanoic acid
 related_synonym: 3-BP;   3-Bromopyruvate;   Formula=C3H3BrO3;   InChI=1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7);   InChIKey=PRRZDZJYSJLDBS-UHFFFAOYSA-N;   SMILES=C(O)(C(=O)CBr)=O;   bromopyruvate;   bromopyruvic acid
 xref: CAS:1113-59-3 "ChemIDplus"
 xref_mesh: MESH:C017092
 xref: MetaCyc:3-BROMOPYRUVATE;   PMID:26053972 "Europe PMC";   PMID:26530887 "Europe PMC";   PMID:26708213 "Europe PMC";   PMID:26715289 "Europe PMC";   PMID:26740252 "Europe PMC";   PMID:26815411 "Europe PMC";   PMID:26825851 "Europe PMC";   PMID:26862728 "Europe PMC";   PMID:26922560 "Europe PMC";   Reaxys:1746786 "Reaxys";   Wikipedia:Bromopyruvic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:131592


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3-bromopyruvic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hk1 hexokinase 1 JBrowse link 20 31,911,460 31,979,780 RGD:6480464
G Hk2 hexokinase 2 JBrowse link 4 113,559,396 113,609,897 RGD:6480464
G Ldha lactate dehydrogenase A JBrowse link 1 102,900,288 102,909,713 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Sdha succinate dehydrogenase complex flavoprotein subunit A JBrowse link 1 31,545,631 31,570,601 RGD:6480464
G Slc16a1 solute carrier family 16 member 1 JBrowse link 2 207,108,552 207,129,352 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        biochemical role 19179
          cofactor 15389
            pyruvic acid 47
              3-bromopyruvic acid 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        monocarboxylic acid 17260
                                          fatty acid 15814
                                            saturated fatty acid 15781
                                              propionic acid 3640
                                                pyruvic acid 47
                                                  3-bromopyruvic acid 17
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.