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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor
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Accession:CHEBI:131794 term browser browse the term
Definition:Any EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of a Ca(2+)/calmodulin-dependent protein kinase (EC 2.7.11.17).
Synonyms:related_synonym: ATP:caldesmon O-phosphotransferase inhibitor;   ATP:caldesmon O-phosphotransferase inhibitors;   ATP:protein phosphotransferase ((2+)/calmodulin-dependent) inhibitor;   ATP:protein phosphotransferase ((2+)/calmodulin-dependent) inhibitors;   CAM PKII inhibitor;   CAM PKII inhibitors;   Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase inhibitor;   Ca(2+)/calmodulin-dependent microtubule-associated protein 2 kinase inhibitors;   Ca(2+)/calmodulin-dependent protein kinase (EC 2.7.11.17) inhibitors;   Ca(2+)/calmodulin-dependent protein kinase 1 inhibitor;   Ca(2+)/calmodulin-dependent protein kinase 1 inhibitors;   Ca(2+)/calmodulin-dependent protein kinase II inhibitor;   Ca(2+)/calmodulin-dependent protein kinase II inhibitors;   Ca(2+)/calmodulin-dependent protein kinase IV inhibitor;   Ca(2+)/calmodulin-dependent protein kinase IV inhibitors;   Ca(2+)/calmodulin-dependent protein kinase inhibitor;   Ca(2+)/calmodulin-dependent protein kinase inhibitors;   Ca(2+)/calmodulin-dependent protein kinase kinase beta inhibitor;   Ca(2+)/calmodulin-dependent protein kinase kinase beta inhibitors;   Ca(2+)/calmodulin-dependent protein kinase kinase inhibitor;   Ca(2+)/calmodulin-dependent protein kinase kinase inhibitors;   CaM kinase II inhibitor;   CaM kinase II inhibitors;   CaM kinase inhibitor;   CaM kinase inhibitors;   CaM-regulated serine/threonine kinase inhibitor;   CaM-regulated serine/threonine kinase inhibitors;   CaMKI inhibitor;   CaMKI inhibitors;   CaMKII inhibitor;   CaMKII inhibitors;   CaMKIV inhibitor;   CaMKIV inhibitors;   CaMKKalpha inhibitor;   CaMKKalpha inhibitors;   CaMKKbeta inhibitor;   CaMKKbeta inhibitors;   EC 2.7.11.17 inhibitor;   EC 2.7.11.17 inhibitors;   STK20 inhibitor;   STK20 inhibitors;   caldesmon kinase (phosphorylating) inhibitor;   caldesmon kinase (phosphorylating) inhibitors;   caldesmon kinase inhibitor;   caldesmon kinase inhibitors;   calmodulin-dependent kinase II inhibitor;   calmodulin-dependent kinase II inhibitors;   microtubule-associated protein 2 kinase inhibitor;   microtubule-associated protein 2 kinase inhibitors
 xref: Wikipedia:CAMK


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KN-93 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP KN 93 inhibits the reaction [Digoxin results in increased expression of ABCB1 protein]; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] CTD PMID:19647009 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACO1 aconitase 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride affects the localization of ACO1 protein] CTD PMID:25106854 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein] CTD PMID:32522522 NCBI chr19:11,574,660...11,578,983
Ensembl chr19:11,574,660...11,579,008
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein] CTD PMID:18089838 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AHRR aryl-hydrocarbon receptor repressor multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHRR mRNA] CTD PMID:18089838 NCBI chr 5:321,714...438,285
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
Ensembl chr 5:322,587...438,291
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein] CTD PMID:18506790 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of AKT1 protein]
CTD PMID:19233221, PMID:21933187, PMID:28025122 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein] CTD PMID:29883672 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G CALCR calcitonin receptor multiple interactions ISO KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 7:93,424,486...93,574,730
Ensembl chr 7:93,424,486...93,574,730
Ensembl chr 7:93,424,486...93,574,730
JBrowse link
G CAMK1 calcium/calmodulin dependent protein kinase I decreases activity EXP KN 93 results in decreased activity of CAMK1 protein CTD PMID:12193581 NCBI chr 3:9,757,345...9,769,987
Ensembl chr 3:9,757,347...9,769,992
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha multiple interactions ISO
EXP
[KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; KN 93 inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]
KN 93 inhibits the reaction [rutacarpine results in increased phosphorylation of CAMK2A protein]
KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of CAMK2A protein]; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]
CTD PMID:19217379, PMID:21933187, PMID:25103225, PMID:28025122 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,291
JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta multiple interactions ISO KN 93 inhibits the reaction [Cadmium affects the localization of CAMK2D protein] CTD PMID:22553113 NCBI chr 4:113,451,032...113,762,177
Ensembl chr 4:113,451,032...113,761,927
JBrowse link
G CAMK4 calcium/calmodulin dependent protein kinase IV multiple interactions ISO KN 93 inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] CTD PMID:17973980 NCBI chr 5:111,223,583...111,498,503
Ensembl chr 5:111,223,653...111,494,886
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP12 protein] CTD PMID:29883672 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP3 caspase 3 multiple interactions ISO
EXP
KN 93 inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; KN 93 promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]
KN 93 inhibits the reaction [bisphenol A results in increased expression of and results in increased cleavage of CASP3 protein]; KN 93 inhibits the reaction [GW 7845 results in increased activity of CASP3 protein]
CTD PMID:19233221, PMID:20810541, PMID:26096086, PMID:26923100, PMID:28025122, PMID:29883672 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCL1 C-C motif chemokine ligand 1 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL1 mRNA] CTD PMID:18089838 NCBI chr17:34,360,328...34,363,233
Ensembl chr17:34,360,328...34,363,233
JBrowse link
G CCND1 cyclin D1 decreases expression EXP KN 93 results in decreased expression of CCND1 protein CTD PMID:15958590 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]; KN 93 inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] CTD PMID:15385614, PMID:15631885, PMID:21113126 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL8 mRNA] CTD PMID:18089838 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO KN 93 inhibits the reaction [GW 7845 affects the localization of CYCS protein] CTD PMID:20810541 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 multiple interactions EXP KN 93 inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA] CTD PMID:12193581 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP
ISO
KN 93 inhibits the reaction [STO 609 results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:18089838, PMID:18755850, PMID:23298284 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:18089838 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of DDIT3 protein] CTD PMID:29883672 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DRD3 dopamine receptor D3 multiple interactions ISO KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]; KN 93 inhibits the reaction [Ionomycin results in increased phosphorylation of DRD3 protein] CTD PMID:19217379 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EGFR protein] CTD PMID:19233221 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:21933187 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP KN 93 inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein] CTD PMID:23673518 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of GFAP protein] CTD PMID:21879721 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions ISO KN 93 inhibits the reaction [Capsaicin results in increased phosphorylation of GRIA1 protein] CTD PMID:12019337 NCBI chr 5:153,490,670...153,813,873
Ensembl chr 5:153,489,615...153,813,869
JBrowse link
G HDAC5 histone deacetylase 5 multiple interactions ISO KN 93 inhibits the reaction [Potassium Chloride results in increased phosphorylation of HDAC5 protein] CTD PMID:17988634 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions ISO KN 93 inhibits the reaction [Ionomycin results in increased secretion of HEXB protein] CTD PMID:14499669 NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP KN 93 inhibits the reaction [Digoxin affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Digoxin results in increased phosphorylation of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein] CTD PMID:19647009 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 mRNA]; KN 93 inhibits the reaction [rutacarpine results in increased expression of HMOX1 protein] CTD PMID:28025122 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO KN 93 inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein] CTD PMID:29883672 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA] CTD PMID:18089838 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G ITGB7 integrin subunit beta 7 multiple interactions EXP KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA] CTD PMID:18089838 NCBI chr12:53,191,318...53,207,375
Ensembl chr12:53,191,323...53,207,282
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO KN 93 inhibits the reaction [Phenylephrine results in increased activity of MAP3K5 protein] CTD PMID:15629441 NCBI chr 6:136,557,046...136,793,098
Ensembl chr 6:136,557,046...136,792,477
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK1 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK1 protein]
CTD PMID:15086530, PMID:15355987, PMID:19233221, PMID:21879721, PMID:21933187, PMID:28181390, PMID:29883672 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK14 protein] CTD PMID:21933187 NCBI chr 6:36,027,711...36,122,964
Ensembl chr 6:36,027,677...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]
KN 93 affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]
KN 93 inhibits the reaction [cadmium acetate results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of MAPK3 protein]; KN 93 inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased phosphorylation of MAPK3 protein]
CTD PMID:15086530, PMID:15355987, PMID:19233221, PMID:21879721, PMID:21933187, PMID:28181390, PMID:29883672 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:21933187 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions ISO Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]] CTD PMID:25093688 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G NEFL neurofilament light multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFL protein] CTD PMID:21879721 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,957,110
Ensembl chr 8:24,950,955...24,957,110
JBrowse link
G NEFM neurofilament medium multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of NEFM protein] CTD PMID:21879721 NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098
JBrowse link
G NFATC1 nuclear factor of activated T cells 1 multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein] CTD PMID:32522522 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO KN 93 inhibits the reaction [Phenylephrine results in increased degradation of NFKBIA protein] CTD PMID:15629441 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation EXP KN 93 results in decreased phosphorylation of RB1 protein CTD PMID:15958590 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21933187 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO KN 93 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of SRC protein] CTD PMID:19233221 NCBI chr20:37,344,690...37,406,050
Ensembl chr20:37,344,685...37,406,050
JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of ACP5 protein]; KN 93 affects the reaction [[Cadmium co-treated with TNFSF11 protein co-treated with CSF1R protein] affects the expression of NFATC1 protein]; KN 93 inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564, PMID:32522522 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
JBrowse link
G VIM vimentin multiple interactions ISO KN 93 inhibits the reaction [diphenylditelluride results in increased phosphorylation of VIM protein] CTD PMID:21879721 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                  EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor 53
                    2-cyclopentyl-4-[5-(3-methylphenyl)furo[2,3-b]pyridin-3-yl]benzoic acid 0
                    KN-93 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                protein kinase inhibitor 14047
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                    EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor 53
                      2-cyclopentyl-4-[5-(3-methylphenyl)furo[2,3-b]pyridin-3-yl]benzoic acid 0
                      KN-93 53
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.