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Accession:CHEBI:131848 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-fotemustine. It is an alkylating agent used in the treatment of malignant melanoma.
Synonyms:related_synonym: (+-)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate;   Formula=C9H19ClN3O5P;   Muphoran;   Mustoforan;   S 10036;   Servier-10036;   diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate;   fotemustina;   fotemustinum;   rac-fotemustine
 alt_id: MESH:C054368
 xref: CAS:92118-27-9 "ChemIDplus";   KEGG:D07255
 xref_mesh: MESH:C054368
 xref: PMID:15020614 "Europe PMC";   PMID:23560594 "Europe PMC";   PMID:24023343 "Europe PMC";   PMID:24800248 "Europe PMC";   PMID:25538176 "Europe PMC";   PMID:25702193 "Europe PMC";   PMID:2627116 "Europe PMC";   PMID:26458240 "Europe PMC";   PMID:26542177 "Europe PMC";   PMID:26750128 "Europe PMC";   PMID:26951379 "Europe PMC";   PMID:27057436 "Europe PMC";   Patent:FR2536075;   Patent:US4567169;   Reaxys:8626774 "Reaxys";   Wikipedia:Fotemustine

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fotemustine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Mgmt O-6-methylguanine-DNA methyltransferase JBrowse link 1 209,237,255 209,464,189 RGD:6480464
G Polh DNA polymerase eta JBrowse link 9 17,163,354 17,198,006 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    chemical entity 19732
      chemical substance 11495
        mixture 10817
          racemate 9696
            fotemustine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        carboacyl group 17074
                                          univalent carboacyl group 17074
                                            carbamoyl group 16804
                                              carboxamide 16804
                                                monocarboxylic acid amide 14167
                                                  urea 4955
                                                    ureas 4952
                                                      N-nitrosoureas 1909
                                                        diethyl (1-\{[(2-chloroethyl)(nitroso)carbamoyl]amino\}ethyl)phosphonate 10
                                                          (R)-fotemustine 10
                                                            fotemustine 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.