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ONTOLOGY REPORT - ANNOTATIONS


Term:680C91
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Accession:CHEBI:131851 term browser browse the term
Definition:A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin.
Synonyms:exact_synonym: 6-fluoro-3-[(E)-2-(pyridin-3-yl)vinyl]-1H-indole
 related_synonym: Formula=C15H11FN2;   InChI=1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+;   InChIKey=YBSDQTBCNYWBMX-ONEGZZNKSA-N;   SMILES=C=1(C=CC2=C(C1)NC=C2/C=C/C=3C=NC=CC3)F
 xref: CAS:163239-22-3 "SUBMITTER"
 xref_mesh: MESH:C093792
 xref: PMID:7539265 "Europe PMC";   PMID:7617147 "Europe PMC";   PMID:8906241 "Europe PMC";   Reaxys:7640361 "Reaxys"


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680C91 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Polk DNA polymerase kappa JBrowse link 2 27,305,718 27,364,906 RGD:6480464
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link 2 180,897,059 180,914,919 RGD:6480464

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  CHEBI ontology 19754
    chemical entity 19753
      atom 19752
        nonmetal atom 19624
          carbon atom 19517
            organic molecular entity 19517
              olefinic compound 14447
                680C91 4
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  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      carbon group element atom 19528
                        carbon atom 19517
                          organic molecular entity 19517
                            organic molecule 19436
                              organic cyclic compound 19199
                                organic heterocyclic compound 18276
                                  organic heteropolycyclic compound 17583
                                    organic heterobicyclic compound 16252
                                      benzopyrrole 9339
                                        indoles 9200
                                          haloindole 4
                                            fluoroindole 4
                                              680C91 4
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