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ONTOLOGY REPORT - ANNOTATIONS


Term:triptonide
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Accession:CHEBI:132267 term browser browse the term
Definition:A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.
Synonyms:exact_synonym: (3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-6a-isopropyl-8b-methyl-3b,4,4a,7a,7b,8b,9,10-octahydrotrisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione
 related_synonym: Formula=C20H22O6;   InChI=1S/C20H22O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14H,4-7H2,1-3H3/t11-,12-,13-,14-,17-,18-,19+,20+/m0/s1;   InChIKey=SWOVVKGLGOOUKI-ZHGGVEMFSA-N;   SMILES=[C@]123[C@]4(CCC5=C([C@@]4(C[C@H]6[C@]3(C([C@@]7([C@H]([C@@H]1O2)O7)C(C)C)=O)O6)[H])COC5=O)C
 xref: CBA:292103 "Europe PMC"
 xref_mesh: MESH:C084079
 xref: PMID:10774048 "Europe PMC";   PMID:12903464 "Europe PMC";   PMID:24346247 "Europe PMC";   PMID:25296383 "Europe PMC";   PMID:25308753 "Europe PMC";   PMID:5072337 "Europe PMC";   PMID:8237400 "Europe PMC";   PMID:9863222 "Europe PMC";   Pubchem:65411 "SUBMITTER";   Reaxys:5313008 "Reaxys"


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triptonide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:6480464
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:6480464
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        anti-inflammatory agent 14942
          triptonide 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic ester 13967
                                        lactone 5864
                                          gamma-lactone 1194
                                            butenolide 339
                                              triptonide 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.