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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor
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Accession:CHEBI:132365 term browser browse the term
Definition:An EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor that interferes with the action of procollagen-proline dioxygenase (EC 1.14.11.2).
Synonyms:related_synonym: EC 1.14.11.2 inhibitor;   EC 1.14.11.2 inhibitors;   collagen proline hydroxylase inhibitor;   collagen proline hydroxylase inhibitors;   peptidyl proline hydroxylase inhibitor;   peptidyl proline hydroxylase inhibitors;   procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor;   procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors;   procollagen-proline 4-dioxygenase inhibitor;   procollagen-proline 4-dioxygenase inhibitors;   procollagen-proline dioxygenase (EC 1.14.11.2) inhibitors;   procollagen-proline dioxygenase inhibitor;   procollagen-proline dioxygenase inhibitors;   procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitor;   procollagen-proline,2-oxoglutarate-4-dioxygenase inhibitors;   proline hydroxylase inhibitor;   proline hydroxylase inhibitors;   proline protocollagen hydroxylase inhibitor;   proline protocollagen hydroxylase inhibitors;   proline, 2-oxoglutarate dioxygenase inhibitor;   proline, 2-oxoglutarate dioxygenase inhibitors;   proline,2-oxoglutarate 4-dioxygenase inhibitor;   proline,2-oxoglutarate 4-dioxygenase inhibitors;   prolyl 4-hydroxylase inhibitor;   prolyl 4-hydroxylase inhibitors;   prolyl hydroxylase inhibitor;   prolyl hydroxylase inhibitors;   prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitor;   prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating inhibitors;   prolylprotocollagen dioxygenase inhibitor;   prolylprotocollagen dioxygenase inhibitors;   prolylprotocollagen hydroxylase inhibitor;   prolylprotocollagen hydroxylase inhibitors;   protocollagen hydroxylase inhibitor;   protocollagen hydroxylase inhibitors;   protocollagen proline 4-hydroxylase inhibitor;   protocollagen proline 4-hydroxylase inhibitors;   protocollagen proline dioxygenase inhibitor;   protocollagen proline dioxygenase inhibitors;   protocollagen prolyl hydroxylase inhibitor;   protocollagen prolyl hydroxylase inhibitors
 xref: Wikipedia:Procollagen-proline_dioxygenase


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3,4-dihydroxybenzoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Eno1 enolase 1 JBrowse link 5 167,288,223 167,299,610 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:6480464
G Glo1 glyoxalase 1 JBrowse link 20 9,273,589 9,291,608 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ldhc lactate dehydrogenase C JBrowse link 1 102,914,875 102,931,843 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nfkbib NFKB inhibitor beta JBrowse link 1 86,941,073 86,948,845 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
ethyl 3,4-dihydroxybenzoate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:6480464
G Klf2 Kruppel-like factor 2 JBrowse link 16 19,223,087 19,225,037 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Sp7 Sp7 transcription factor JBrowse link 7 143,957,316 143,967,488 RGD:6480464
G Taz tafazzin JBrowse link X 156,421,006 156,429,461 RGD:6480464

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        biochemical role 19190
          enzyme inhibitor 18085
            EC 1.* (oxidoreductase) inhibitor 16469
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 14191
                EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor 38
                  EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor 34
                    3,4-dihydroxybenzoic acid + 34
                    ethyl 3,4-dihydroxybenzoate 6
                    roxadustat 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.