Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


go back to main search page
Accession:CHEBI:132893 term browser browse the term
Definition:A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from Stephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity.
Synonyms:exact_synonym: (1beta)-6,6',12-trimethoxy-2,2'-dimethylberbaman-7-ol
 related_synonym: (+)-limacine;   (1beta)-2,2'-dimethyl-6,6',12-trimethoxyberbaman-7-ol;   7-O-demethyltetrandrine;   Formula=C37H40N2O6;   InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29-/m0/s1;   InChIKey=IIQSJHUEZBTSAT-VMPREFPWSA-N;   SMILES=O1C=2C=C3C(=CC2OC)CCN([C@H]3CC4=CC=C(OC=5C=C(C[C@@]6(N(CCC=7C6=C1C(O)=C(OC)C7)C)[H])C=CC5OC)C=C4)C
 xref: CAS:436-77-1
 xref_mesh: MESH:C060802
 xref: PMID:18161288;   PMID:19428795;   PMID:19764054;   PMID:20030508;   PMID:20208355;   PMID:21418191;   PMID:22130369;   PMID:22720080;   PMID:23112944;   PMID:23401195;   PMID:23452799;   PMID:23596478;   PMID:24568493;   PMID:24856768;   PMID:25539072;   PMID:25645647;   PMID:25754692;   PMID:25872479;   PMID:26408176;   PMID:26512898;   PMID:26893655;   Reaxys:78975;   Wikipedia:Fangchinoline

show annotations for term's descendants       view all columns           Sort by:
fangchinoline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      chemical role 19258
        antioxidant 14222
          fangchinoline 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    p-block element atom 19664
                      carbon group element atom 19559
                        carbon atom 19548
                          organic molecular entity 19548
                            heteroorganic entity 19145
                              organonitrogen compound 18254
                                alkaloid 5318
                                  isoquinoline alkaloid 1127
                                    benzylisoquinoline alkaloid 211
                                      bisbenzylisoquinoline alkaloid 115
                                        fangchinoline 7
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.