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Accession:CHEBI:133021 term browser browse the term
Definition:A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.
Synonyms:exact_synonym: 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-(3-nitro-4-{[(oxan-4-yl)methyl]amino}benzene-1-sulfonyl)-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide
 related_synonym: ABT 199;   ABT199;   Formula=C45H50ClN7O7S;   GDC 0199;   InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54);   InChIKey=LQBVNQSMGBZMKD-UHFFFAOYSA-N;   SMILES=C1N(CCN(C1)C2=CC=C(C(NS(C3=CC=C(C(=C3)[N+](=O)[O-])NCC4CCOCC4)(=O)=O)=O)C(=C2)OC=5C=C6C(=NC5)NC=C6)CC=7CCC(CC7C=8C=CC(=CC8)Cl)(C)C;   Venclexta
 xref: CAS:1257044-40-8 "ChemIDplus";   CAS:1257044-40-8 "KEGG DRUG";   Drug_Central:5133 "DrugCentral";   KEGG:D10679
 xref_mesh: MESH:C579720
 xref: PMID:24794804 "Europe PMC";   PMID:25185206 "Europe PMC";   PMID:25658896 "Europe PMC";   PMID:25768998 "Europe PMC";   PMID:25829398 "Europe PMC";   PMID:25882699 "Europe PMC";   PMID:25957396 "Europe PMC";   PMID:26110568 "Europe PMC";   PMID:26467384 "Europe PMC";   PMID:26493374 "Europe PMC";   PMID:26516589 "Europe PMC";   PMID:26565405 "Europe PMC";   PMID:26589495 "Europe PMC";   PMID:26711339 "Europe PMC";   PMID:26927160 "Europe PMC";   PMID:26967820 "Europe PMC";   PMID:27030982 "Europe PMC";   PMID:27056887 "Europe PMC";   PMID:27092880 "Europe PMC";   PMID:27095788 "Europe PMC";   PMID:27103402 "Europe PMC";   PMID:27166183 "Europe PMC";   PMID:27283158 "Europe PMC";   PMID:27466751 "Europe PMC";   PMID:27480872 "Europe PMC";   Reaxys:20908256 "Reaxys";   Wikipedia:Venetoclax

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venetoclax term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        inhibitor 18163
          B-cell lymphoma 2 inhibitor 1
            venetoclax 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    main group molecular entity 19622
                      s-block molecular entity 19388
                        hydrogen molecular entity 19377
                          hydrides 18283
                            inorganic hydride 17204
                              pnictogen hydride 17166
                                nitrogen hydride 17001
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        tertiary amino compound 8544
                                          N-alkylpiperazine 3030
                                            venetoclax 1
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.