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ONTOLOGY REPORT - ANNOTATIONS


Term:N-hydroxy-PhIP
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Accession:CHEBI:133920 term browser browse the term
Definition:An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP.
Synonyms:exact_synonym: N-(1-methyl-6-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ylidene)hydroxylamine
 related_synonym: 2-Hydroxyamino-PhIP;   2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine;   Formula=C13H12N4O;   InChI=1S/C13H12N4O/c1-17-11-7-10(9-5-3-2-4-6-9)8-14-12(11)15-13(17)16-18/h2-8,18H,1H3,(H,14,15,16);   InChIKey=DCVWQAGUQFBCTF-UHFFFAOYSA-N;   N-OH-PhIP;   SMILES=CN1C=2C=C(C=NC2N=C1NO)C3=CC=CC=C3
 xref: CAS:124489-20-9 "ChemIDplus";   CAS:124489-20-9 "KEGG COMPOUND";   ChemIDplus:94711 "Chemspider";   KEGG:C20286
 xref_mesh: MESH:C060533
 xref: PMID:10357796 "Europe PMC";   PMID:10837010 "Europe PMC";   PMID:11196146 "Europe PMC";   PMID:11408353 "Europe PMC";   PMID:11442279 "Europe PMC";   PMID:11700987 "Europe PMC";   PMID:11834212 "Europe PMC";   PMID:12175520 "Europe PMC";   PMID:12473729 "Europe PMC";   PMID:12773763 "Europe PMC";   PMID:15310245 "Europe PMC";   PMID:16137733 "Europe PMC";   PMID:17122891 "Europe PMC";   PMID:17638922 "Europe PMC";   PMID:20708442 "Europe PMC";   PMID:2233839 "Europe PMC";   PMID:24334255 "Europe PMC";   PMID:24718704 "Europe PMC";   PMID:25815793 "Europe PMC";   PMID:26270892 "Europe PMC";   PMID:27032077 "Europe PMC";   PMID:27984695 "Europe PMC";   PMID:7728954 "Europe PMC";   PMID:7852185 "Europe PMC";   PMID:8142010 "Europe PMC";   PMID:8199311 "Europe PMC";   PMID:8600367 "Europe PMC";   PMID:9760588 "Europe PMC";   Reaxys:8393164 "Reaxys"


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N-hydroxy-PhIP term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:6480464
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:6480464
G Gsta4 glutathione S-transferase alpha 4 JBrowse link 8 85,497,557 85,514,732 RGD:6480464
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Nat1 N-acetyltransferase 1 JBrowse link 16 23,970,742 23,991,573 RGD:6480464
G Nat2 N-acetyltransferase 2 JBrowse link 16 23,960,709 23,991,570 RGD:6480464
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:6480464
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:6480464
G Rps7 ribosomal protein S7 JBrowse link 6 47,899,525 47,904,389 RGD:6480464
G Sar1a secretion associated, Ras related GTPase 1A JBrowse link 20 31,298,269 31,310,676 RGD:6480464
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:6480464
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 JBrowse link 9 95,256,628 95,302,822 RGD:6480464
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:6480464
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        aetiopathogenetic role 18761
          genotoxin 16053
            N-hydroxy-PhIP 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    main group molecular entity 19539
                      s-block molecular entity 19322
                        hydrogen molecular entity 19312
                          hydrides 18241
                            inorganic hydride 17110
                              pnictogen hydride 17068
                                nitrogen hydride 16889
                                  azane 16565
                                    ammonia 16562
                                      organic amino compound 16561
                                        primary amino compound 6641
                                          PhIP 573
                                            N-hydroxy-PhIP 23
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.