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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:capsiate
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Accession:CHEBI:134190 term browser browse the term
Definition:A carboxylic ester obtained by formal condensation of the carboxy group of (6E)-8-methylnon-6-enoic acid with the benzylic hydroxy group of vanillyl alcohol. A non-pungent analogue of capsaicin with a similar biological profile.
Synonyms:exact_synonym: (4-hydroxy-3-methoxyphenyl)methyl (6E)-8-methylnon-6-enoate
 related_synonym: Formula=C18H26O4;   InChI=1S/C18H26O4/c1-14(2)8-6-4-5-7-9-18(20)22-13-15-10-11-16(19)17(12-15)21-3/h6,8,10-12,14,19H,4-5,7,9,13H2,1-3H3/b8-6+;   InChIKey=ZICNYIDDNJYKCP-SOFGYWHQSA-N;   SMILES=CC(C)\\C=C\\CCCCC(=O)OCC=1C=CC(=C(C1)OC)O;   vanillyl (6E)-8-methylnon-6-enoate
 xref: AGR:IND44385191;   CAS:205687-01-0;   Chemspider:8015237;   HMDB:HMDB0034780;   KEGG:C20203
 xref_mesh: MESH:C470213
 xref: PMID:12726827;   PMID:12959953;   PMID:16636441;   PMID:17264228;   PMID:17971242;   PMID:18172315;   PMID:19773740;   PMID:20102390;   PMID:20123015;   PMID:21071592;   PMID:21878735;   PMID:21883144;   PMID:21928164;   PMID:22038945;   PMID:23026494;   PMID:24026939;   PMID:24102723;   PMID:24644244;   PMID:25806854;   PMID:26030806;   PMID:28001433;   PMID:28230360;   PMID:28569248;   Reaxys:7933697


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capsiate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd69 Cd69 molecule decreases localization ISO capsiate analog results in decreased localization of CD69 protein CTD PMID:12115659 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases localization ISO capsiate analog results in decreased localization of ICAM1 protein CTD PMID:12115659 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO capsiate results in increased expression of IGF1 protein CTD PMID:17307377 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased activity of IKBKG protein] CTD PMID:12115659 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases localization ISO capsiate analog results in decreased localization of IL2RA protein CTD PMID:12115659 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO capsiate analog inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Plant Preparations] results in increased degradation of NFKBIA protein] CTD PMID:12115659 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP capsiate results in decreased expression of UCP3 mRNA CTD PMID:17264228 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      chemical role 19288
        antioxidant 14226
          capsiate 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                carbocyclic compound 18222
                                  benzenoid aromatic compound 17254
                                    benzenes 17010
                                      methoxybenzenes 1835
                                        monomethoxybenzene 1741
                                          guaiacols 1355
                                            vanillyl alcohol 8
                                              capsiate 7
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