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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pyrovalerone
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Accession:CHEBI:134998 term browser browse the term
Synonyms:related_synonym: Formula=C16H23NO;   InChI=1S/C16H23NO/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14/h7-10,15H,3-6,11-12H2,1-2H3;   InChIKey=SWUVZKWCOBGPTH-UHFFFAOYSA-N;   SMILES=C(C(=O)C1=CC=C(C=C1)C)(CCC)N2CCCC2;   pyrovalerone HCl;   pyrovalerone hydrochloride
 xref: CAS:3563-49-3;   Drug_Central:3511
 xref_mesh: MESH:C005719


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pyrovalerone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO pyrovalerone analog results in increased expression of BAX protein CTD PMID:28578026 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO pyrovalerone analog results in decreased expression of BCL2 protein CTD PMID:28578026 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO pyrovalerone analog results in increased expression of BECN1 protein
Acetylcysteine inhibits the reaction [pyrovalerone analog results in increased expression of BECN1 protein]
CTD PMID:28578026 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [pyrovalerone analog results in increased activity of CASP3 protein] CTD PMID:28578026 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO pyrovalerone analog results in increased activity of CASP9 protein CTD PMID:28578026 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity ISO pyrovalerone analog results in decreased activity of GSR protein CTD PMID:28578026 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [pyrovalerone analog results in decreased expression of SQSTM1 protein] CTD PMID:28578026 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      group 19698
        inorganic group 19168
          oxo group 18404
            organic oxo compound 18404
              carbonyl compound 18404
                ketone 16152
                  aromatic ketone 11909
                    pyrovalerone 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      ketone 16152
                                        aromatic ketone 11909
                                          pyrovalerone 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.