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ONTOLOGY REPORT - ANNOTATIONS


Term:neticonazole
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Accession:CHEBI:135281 term browser browse the term
Definition:An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections.
Synonyms:exact_synonym: 1-{(E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole
 related_synonym: Atolant;   Formula=C17H22N2OS;   InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+;   InChIKey=VWOIKFDZQQLJBJ-DTQAZKPQSA-N;   SMILES=C(=C\\SC)(\\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2;   neticonazol;   neticonazolum
 xref: CAS:130726-68-0 "ChemIDplus";   CAS:130726-68-0 "DrugCentral";   Drug_Central:1902 "DrugCentral"
 xref_mesh: MESH:C084784
 xref: PMID:11156023 "Europe PMC";   PMID:16651719 "Europe PMC";   PMID:8254891 "Europe PMC";   PMID:8734665 "Europe PMC";   PMID:9062749 "Europe PMC";   Patent:CA2458026;   Patent:EP1568366;   Patent:EP227011;   Patent:US4740601;   Reaxys:5381743 "Reaxys";   Wikipedia:Neticonazole
 cyclic_relationship: is_conjugate_base_of CHEBI:141384


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neticonazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            antifungal drug 5099
              neticonazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic molecule 19431
                              organic cyclic compound 19197
                                organic heterocyclic compound 18267
                                  heteroarene 15809
                                    monocyclic heteroarene 13124
                                      azole 12254
                                        diazole 8077
                                          imidazoles 7629
                                            imidazole antifungal agent 1233
                                              imidazole antifungal drug 764
                                                neticonazole 1
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