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ONTOLOGY REPORT - ANNOTATIONS


Term:neticonazole
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Accession:CHEBI:135281 term browser browse the term
Definition:An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections.
Synonyms:exact_synonym: 1-{(E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole
 related_synonym: Atolant;   Formula=C17H22N2OS;   InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+;   InChIKey=VWOIKFDZQQLJBJ-DTQAZKPQSA-N;   SMILES=C(=C\\SC)(\\C1=C(OCCCCC)C=CC=C1)/N2C=CN=C2;   neticonazol;   neticonazolum
 xref: CAS:130726-68-0;   Drug_Central:1902
 xref_mesh: MESH:C084784
 xref: PMID:11156023;   PMID:16651719;   PMID:8254891;   PMID:8734665;   PMID:9062749;   Patent:CA2458026;   Patent:EP1568366;   Patent:EP227011;   Patent:US4740601;   Reaxys:5381743;   Wikipedia:Neticonazole
 cyclic_relationship: is_conjugate_base_of CHEBI:141384


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neticonazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 1 171,213,934 171,218,845 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 21270
    role 21254
      application 20691
        pharmaceutical 20073
          drug 20073
            antifungal drug 5257
              neticonazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 21270
    subatomic particle 21266
      composite particle 21266
        hadron 21266
          baryon 21266
            nucleon 21266
              atomic nucleus 21266
                atom 21266
                  main group element atom 21135
                    p-block element atom 21135
                      carbon group element atom 20906
                        carbon atom 20796
                          organic molecular entity 20796
                            organic molecule 20679
                              organic cyclic compound 20138
                                organic heterocyclic compound 19018
                                  heteroarene 15977
                                    monocyclic heteroarene 13307
                                      azole 12548
                                        diazole 8252
                                          imidazoles 7758
                                            imidazole antifungal agent 1249
                                              imidazole antifungal drug 774
                                                neticonazole 1
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