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Term:(S)-PGA2-S-glutathione conjugate
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Accession:CHEBI:136106 term browser browse the term
Definition:A glutathione conjugate obtained by formal 1,4-addition of the thiol function of glutathione to the enone function of prostaglandin A2 (where the newly formed stereocentre at position 11 has S-configuration).
Synonyms:exact_synonym: L-gamma-glutamyl-S-[(5Z,11beta,13E,15S)-1,15-dihydroxy-1,9-dioxoprosta-5,13-dien-11-yl]-L-cysteinylglycine
 related_synonym: (S)-PGA2-GSH conjugate;   (S)-prostaglandin A2-S-glutathione conjugate;   Formula=C30H47N3O10S;   InChI=1S/C30H47N3O10S/c1-2-3-6-9-19(34)12-13-21-20(10-7-4-5-8-11-27(37)38)24(35)16-25(21)44-18-23(29(41)32-17-28(39)40)33-26(36)15-14-22(31)30(42)43/h4,7,12-13,19-23,25,34H,2-3,5-6,8-11,14-18,31H2,1H3,(H,32,41)(H,33,36)(H,37,38)(H,39,40)(H,42,43)/b7-4-,13-12+/t19-,20+,21+,22-,23-,25-/m0/s1;   InChIKey=XUKIKVBUXFVHNV-APJWUDRJSA-N;   S-(PGA2)-glutathione;   SMILES=[C@H]1([C@H]([C@H](CC1=O)SC[C@H](NC(CC[C@H](N)C(=O)O)=O)C(=O)NCC(=O)O)/C=C/[C@H](CCCCC)O)C/C=C\\CCCC(=O)O
 xref: PMID:9084911 "Europe PMC";   Reaxys:8964431 "Reaxys"
 cyclic_relationship: is_conjugate_acid_of CHEBI:133769


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  CHEBI ontology 19728
    role 19675
      chemical role 19189
        antioxidant 14093
          glutathione 371
            glutathione derivative 57
              glutathione conjugate 4
                (S)-PGA2-S-glutathione conjugate 0
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  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                peptide 9316
                                                  oligopeptide 1075
                                                    tripeptide 864
                                                      glutathione 371
                                                        glutathione derivative 57
                                                          glutathione conjugate 4
                                                            (S)-PGA2-S-glutathione conjugate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.