Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eupatorin
go back to main search page
Accession:CHEBI:136666 term browser browse the term
Definition:A trimethoxyflavone that is 6-hydroxyluteolin in which the phenolic hydogens at positions 4', 6 and 7 have been replaced by methyl groups.
Synonyms:exact_synonym: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
 related_synonym: 3',5-dihydroxy-4',6,7-trimethoxyflavone;   Eupatorine;   Formula=C18H16O7;   InChI=1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3;   InChIKey=KLAOKWJLUQKWIF-UHFFFAOYSA-N;   SMILES=O1C=2C(=C(O)C(OC)=C(OC)C2)C(=O)C=C1C3=CC(O)=C(OC)C=C3
 xref: AGR:IND43745404;   AGR:IND605417569;   CAS:855-96-9;   Chemspider:87743;   KNApSAcK:C00003894;   LIPID_MAPS_instance:LMPK12111239
 xref_mesh: MESH:C103110
 xref: PMID:18454852;   PMID:19601638;   PMID:22227008;   PMID:22516932;   PMID:22698713;   PMID:22898066;   PMID:23839090;   PMID:24422962;   PMID:25390937;   PMID:25442272;   PMID:25598631;   PMID:26281557;   PMID:26322527;   PMID:26404257;   PMID:26649063;   PMID:26983579;   PMID:27187805;   PMID:27370961;   PMID:27470387;   PMID:27679866;   PMID:27695261;   PMID:27834876;   PMID:27991400;   PMID:28044092;   PMID:28347190;   PMID:29373904;   PMID:5847037;   PMID:905420;   Reaxys:1355109


show annotations for term's descendants           Sort by:
 
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
decreases activity
increases expression
ISO CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA
CTD PMID:18454852, PMID:19601638, PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein
CTD PMID:19601638, PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        anti-inflammatory agent 14965
          eupatorin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  oxacycle 17200
                                    benzopyran 10142
                                      1-benzopyran 9858
                                        flavonoid 6376
                                          flavones 4169
                                            hydroxyflavone 4157
                                              3'-hydroxyflavonoid 240
                                                luteolin 182
                                                  6-hydroxyluteolin 4
                                                    eupatorin 4
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.