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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor
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Accession:CHEBI:137123 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30).
Synonyms:related_synonym: ATP:[receptor-protein] phosphotransferase inhibitor;   ATP:[receptor-protein] phosphotransferase inhibitors;   EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitors;   EC 2.7.11.30 inhibitor;   EC 2.7.11.30 inhibitors;   STK13 inhibitor;   STK13 inhibitors;   TGF-beta kinase inhibitor;   TGF-beta kinase inhibitors;   activin receptor kinase inhibitor;   activin receptor kinase inhibitors;   inhibitor of receptor protein serine/threonine kinase;   receptor protein serine/threonine kinase inhibitors;   receptor serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitors;   receptor type II serine/threonine protein kinase inhibitor;   receptor type II serine/threonine protein kinase inhibitors
 xref: Wikipedia:Receptor_protein_serine/threonine_kinase


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LY 364947 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6480464
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6480464
LY-2157299 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Acan aggrecan JBrowse link 1 140,762,758 140,824,441 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col2a1 collagen type II alpha 1 chain JBrowse link 7 139,454,945 139,484,403 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Lamc2 laminin subunit gamma 2 JBrowse link 13 70,566,643 70,632,126 RGD:6480464
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        inhibitor 18175
          enzyme inhibitor 18097
            EC 2.* (transferase) inhibitor 13520
              EC 2.7.* (P-containing group transferase) inhibitor 13184
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8136
                  EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                    2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                    TGFbeta receptor antagonist + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        inhibitor 18175
          enzyme inhibitor 18097
            EC 2.* (transferase) inhibitor 13520
              EC 2.7.* (P-containing group transferase) inhibitor 13184
                protein kinase inhibitor 12664
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8136
                    EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                      2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                      TGFbeta receptor antagonist + 22
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.