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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor
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Accession:CHEBI:137123 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30).
Synonyms:related_synonym: ATP:[receptor-protein] phosphotransferase inhibitor;   ATP:[receptor-protein] phosphotransferase inhibitors;   EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitors;   EC 2.7.11.30 inhibitor;   EC 2.7.11.30 inhibitors;   STK13 inhibitor;   STK13 inhibitors;   TGF-beta kinase inhibitor;   TGF-beta kinase inhibitors;   activin receptor kinase inhibitor;   activin receptor kinase inhibitors;   inhibitor of receptor protein serine/threonine kinase;   receptor protein serine/threonine kinase inhibitors;   receptor serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitors;   receptor type II serine/threonine protein kinase inhibitor;   receptor type II serine/threonine protein kinase inhibitors
 xref: Wikipedia:Receptor_protein_serine/threonine_kinase


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LY 364947 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA] CTD PMID:25566828 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:23542815 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein] CTD PMID:23542815 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:23542815 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CCN2 cellular communication network factor 2 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA] CTD PMID:25566828 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO [Ly-364947 co-treated with Carbon Tetrachloride] results in increased expression of CDKN1A protein; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in increased expression of CDKN1A mRNA]
Ly-364947 results in decreased expression of CDKN1A protein
CTD PMID:25566828 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:25566828 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases expression
ISO Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]
Ly-364947 results in increased expression of CYP2E1 mRNA
CTD PMID:25566828 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23542815 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23542815 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein] CTD PMID:25566828 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA] CTD PMID:25566828 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SMAD2 SMAD family member 2 multiple interactions
decreases expression
EXP
ISO
Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
Ly-364947 results in decreased expression of SMAD2 protein modified form
Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]
CTD PMID:24727557, PMID:25566828 NCBI chr18:47,808,957...47,931,188
Ensembl chr18:47,808,957...47,931,146
JBrowse link
G SMAD3 SMAD family member 3 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr15:67,065,602...67,195,195
Ensembl chr15:67,063,763...67,195,169
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases activity
multiple interactions
ISO
EXP
Ly-364947 results in decreased activity of TGFB1 protein
Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
CTD PMID:23542815, PMID:24727557 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TGFB3 transforming growth factor beta 3 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link
LY-2157299 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ACAN aggrecan decreases expression ISO LY-2157299 results in decreased expression of ACAN mRNA CTD PMID:29660438 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA CTD PMID:29808285 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression ISO LY-2157299 results in decreased expression of COL2A1 mRNA CTD PMID:29660438 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein CTD PMID:29808285 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein CTD PMID:29808285 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G LAMC2 laminin subunit gamma 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein CTD PMID:29808285 NCBI chr 1:183,186,264...183,245,127
Ensembl chr 1:183,186,238...183,245,127
JBrowse link
G SMAD2 SMAD family member 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr18:47,808,957...47,931,188
Ensembl chr18:47,808,957...47,931,146
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA CTD PMID:29808285 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                  EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                    2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                    TGFbeta receptor antagonist + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        inhibitor 21464
          enzyme inhibitor 21386
            EC 2.* (transferase) inhibitor 14971
              EC 2.7.* (P-containing group transferase) inhibitor 14663
                protein kinase inhibitor 14047
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8672
                    EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                      2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                      TGFbeta receptor antagonist + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.