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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor
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Accession:CHEBI:137123 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30).
Synonyms:related_synonym: ATP:[receptor-protein] phosphotransferase inhibitor;   ATP:[receptor-protein] phosphotransferase inhibitors;   EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitors;   EC 2.7.11.30 inhibitor;   EC 2.7.11.30 inhibitors;   STK13 inhibitor;   STK13 inhibitors;   TGF-beta kinase inhibitor;   TGF-beta kinase inhibitors;   activin receptor kinase inhibitor;   activin receptor kinase inhibitors;   inhibitor of receptor protein serine/threonine kinase;   receptor protein serine/threonine kinase inhibitors;   receptor serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitors;   receptor type II serine/threonine protein kinase inhibitor;   receptor type II serine/threonine protein kinase inhibitors
 xref: Wikipedia:Receptor_protein_serine/threonine_kinase


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LY 364947 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions EXP Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA] CTD PMID:25566828 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:23542815 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein] CTD PMID:23542815 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:23542815 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA] CTD PMID:25566828 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
decreases expression
EXP [Ly-364947 co-treated with Carbon Tetrachloride] results in increased expression of CDKN1A protein; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in increased expression of CDKN1A mRNA]
Ly-364947 results in decreased expression of CDKN1A protein
CTD PMID:25566828 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions EXP Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:25566828 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
EXP Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]
Ly-364947 results in increased expression of CYP2E1 mRNA
CTD PMID:25566828 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23542815 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23542815 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein] CTD PMID:25566828 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions EXP Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA] CTD PMID:25566828 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Smad2 SMAD family member 2 multiple interactions
decreases expression
ISO
EXP
Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
Ly-364947 results in decreased expression of SMAD2 protein modified form
Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]
CTD PMID:24727557, PMID:25566828 NCBI chr18:76,241,090...76,311,748
Ensembl chr18:76,241,580...76,310,963
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr 9:63,646,766...63,757,994
Ensembl chr 9:63,646,767...63,757,994
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity
multiple interactions
ISO Ly-364947 results in decreased activity of TGFB1 protein
Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
CTD PMID:23542815, PMID:24727557 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr12:86,056,743...86,079,041
Ensembl chr12:86,056,745...86,079,041
JBrowse link
LY-2157299 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 multiple interactions EXP [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Acan aggrecan decreases expression ISO LY-2157299 results in decreased expression of ACAN mRNA CTD PMID:29660438 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions EXP [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA CTD PMID:29808285 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO LY-2157299 results in decreased expression of COL2A1 mRNA CTD PMID:29660438 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions EXP [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein CTD PMID:29808285 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein CTD PMID:29808285 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Lamc2 laminin, gamma 2 multiple interactions EXP [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein CTD PMID:29808285 NCBI chr 1:153,122,756...153,186,447
Ensembl chr 1:153,122,756...153,186,447
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr18:76,241,090...76,311,748
Ensembl chr18:76,241,580...76,310,963
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA CTD PMID:29808285 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21538
    role 21517
      biological role 21516
        inhibitor 19287
          enzyme inhibitor 19203
            EC 2.* (transferase) inhibitor 14258
              EC 2.7.* (P-containing group transferase) inhibitor 13940
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8327
                  EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                    2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                    TGFbeta receptor antagonist + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 21538
    role 21517
      biological role 21516
        inhibitor 19287
          enzyme inhibitor 19203
            EC 2.* (transferase) inhibitor 14258
              EC 2.7.* (P-containing group transferase) inhibitor 13940
                protein kinase inhibitor 13402
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8327
                    EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                      2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                      TGFbeta receptor antagonist + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.