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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor
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Accession:CHEBI:137123 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30).
Synonyms:related_synonym: ATP:[receptor-protein] phosphotransferase inhibitor;   ATP:[receptor-protein] phosphotransferase inhibitors;   EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitors;   EC 2.7.11.30 inhibitor;   EC 2.7.11.30 inhibitors;   STK13 inhibitor;   STK13 inhibitors;   TGF-beta kinase inhibitor;   TGF-beta kinase inhibitors;   activin receptor kinase inhibitor;   activin receptor kinase inhibitors;   inhibitor of receptor protein serine/threonine kinase;   receptor protein serine/threonine kinase inhibitors;   receptor serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitor;   receptor type I serine/threonine protein kinase inhibitors;   receptor type II serine/threonine protein kinase inhibitor;   receptor type II serine/threonine protein kinase inhibitors
 xref: Wikipedia:Receptor_protein_serine/threonine_kinase


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LY 364947 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA] CTD PMID:25566828 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:23542815 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein] CTD PMID:23542815 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:23542815 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA] CTD PMID:25566828 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases expression
ISO [Ly-364947 co-treated with Carbon Tetrachloride] results in increased expression of CDKN1A protein; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in increased expression of CDKN1A mRNA]
Ly-364947 results in decreased expression of CDKN1A protein
CTD PMID:25566828 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:25566828 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
ISO Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; Ly-364947 inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 protein]
Ly-364947 results in increased expression of CYP2E1 mRNA
CTD PMID:25566828 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23542815 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Ly-364947 inhibits the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23542815 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Ly-364947 promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein] CTD PMID:25566828 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA] CTD PMID:25566828 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Smad2 SMAD family member 2 multiple interactions
decreases expression
ISO Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
Ly-364947 results in decreased expression of SMAD2 protein modified form
Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]
CTD PMID:24727557, PMID:25566828 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity
multiple interactions
EXP
ISO
Ly-364947 results in decreased activity of TGFB1 protein
Ly-364947 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]
CTD PMID:23542815, PMID:24727557 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO Ly-364947 affects the reaction [TGFB3 protein results in increased expression of SERPINE1 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of ACTA2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of CCN2 mRNA]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD2 protein modified form]; Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
LY-2157299 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA; [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acan aggrecan decreases expression EXP LY-2157299 results in decreased expression of ACAN mRNA CTD PMID:29660438 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of COL1A1 mRNA CTD PMID:29808285 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP LY-2157299 results in decreased expression of COL2A1 mRNA CTD PMID:29660438 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of CTNNB1 protein CTD PMID:29808285 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of FN1 protein CTD PMID:29808285 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Lamc2 laminin subunit gamma 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of LAMC2 protein CTD PMID:29808285 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the phosphorylation of SMAD2 protein CTD PMID:29808285 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [ABCB4 protein affects the susceptibility to LY-2157299] which affects the expression of TGFB1 mRNA CTD PMID:29808285 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        inhibitor 18247
          enzyme inhibitor 18173
            EC 2.* (transferase) inhibitor 13825
              EC 2.7.* (P-containing group transferase) inhibitor 13505
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8168
                  EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                    2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                    TGFbeta receptor antagonist + 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        inhibitor 18247
          enzyme inhibitor 18173
            EC 2.* (transferase) inhibitor 13825
              EC 2.7.* (P-containing group transferase) inhibitor 13505
                protein kinase inhibitor 13032
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8168
                    EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor 22
                      2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine 0
                      TGFbeta receptor antagonist + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.