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Accession:CHEBI:139047 term browser browse the term
Definition:A pyrrolopyrimidine that is 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor.
Synonyms:exact_synonym: 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
 related_synonym: 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)-ethanone;   Formula=C23H21FN6O;   InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27);   InChIKey=PRWSIEBRGXYXAJ-UHFFFAOYSA-N;   PERK inhibitor;   SMILES=C=1(C2=C(N=CN1)N(C)C=C2C=3C(=C4C(=CC3)N(CC4)C(CC5=CC=CC(=N5)C)=O)F)N
 xref: CAS:1337532-29-2 "SUBMITTER"
 xref_mesh: MESH:C000597302
 xref: PMID:23333938 "Europe PMC";   PMID:24401334 "Europe PMC";   PMID:24900593 "Europe PMC";   PMID:27251848 "Europe PMC";   PMID:27682474 "Europe PMC";   PMID:28212323 "Europe PMC";   PMID:28452996 "Europe PMC";   PMID:28522733 "Europe PMC";   PMID:28641278 "Europe PMC";   PMID:28672279 "Europe PMC";   PMID:28686850 "Europe PMC";   PMID:28763567 "Europe PMC";   PMID:28867195 "Europe PMC";   Reaxys:21981813 "Reaxys"

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GSK2656157 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:6480464
G Ostn osteocrin JBrowse link 11 76,851,923 76,888,140 RGD:6480464

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  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antineoplastic agent 16877
              GSK2656157 3
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  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                tertiary carboxamide 110
                                                  GSK2656157 3
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