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ONTOLOGY REPORT - ANNOTATIONS


Term:methacetin-(methoxy-(13)C)
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Accession:CHEBI:139355 term browser browse the term
Definition:A (13)C-modified compound that is methacetin which has (13)C as the predominant isotope of the methoxy carbon. In normal subjects, methacetin is rapidly metabolised in the liver, being dealkylated by hepatic CYP1A2 to give paracetamol (acetaminophen); the methyl of the methoxy group is eliminated as CO2. Administering methacetin-(methoxy-(13)C) to a patient enables the liver (cytochrome P-450 1A2) function to be determined quickly and precisely by measuring the (13)CO2 in the breath (e.g. by isotope-selective non-dispersive infrared spectrometry (NDIRS)).
Synonyms:exact_synonym: N-{4-[((13)C)methyloxy]phenyl}acetamide
 related_synonym: (13)C-MBT;   Formula=C8[13C]H11NO2;   InChI=1S/C9H11NO2/c1-7(11)10-8-3-5-9(12-2)6-4-8/h3-6H,1-2H3,(H,10,11)/i2+1;   InChIKey=XVAIDCNLVLTVFM-VQEHIDDOSA-N;   SMILES=C=1C=C(O[13CH3])C=CC1NC(C)=O;   methacetin C-13;   p-acetanisidine C-13
 xref: CAS:72156-70-8;   PMID:17593076;   PMID:18339592;   PMID:18763185;   PMID:19248196;   PMID:19297040;   PMID:20149989;   PMID:21287423;   PMID:21386198;   PMID:21687605;   PMID:22174547;   PMID:22540278;   PMID:22612381;   PMID:22827182;   PMID:23322130;   PMID:23549507;   PMID:23642250;   PMID:23967104;   PMID:25170215;   PMID:26220750;   PMID:26935501;   Reaxys:31580327


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Term Annotations click to browse term
  CHEBI ontology 19758
    chemical entity 19757
      molecular entity 19755
        isotopically modified compound 1
          (13)C-modified compound 0
            methacetin-(methoxy-(13)C) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic group 18428
                              organic divalent group 18419
                                organodiyl group 18419
                                  carbonyl group 18309
                                    carbonyl compound 18309
                                      carboxylic acid 17978
                                        carboacyl group 17095
                                          univalent carboacyl group 17095
                                            carbamoyl group 16818
                                              carboxamide 16818
                                                acetamides 11621
                                                  methacetin-(methoxy-(13)C) 0
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