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ONTOLOGY REPORT - ANNOTATIONS


Term:MC1568
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Accession:CHEBI:140475 term browser browse the term
Definition:A hydroxamic acid that is N-methylpyrrole which is substituted at positions 2 and 5 by 3-(hydroxyamino)-3-oxoprop-1-en-1-yl and 3-(m-fluorophenyl)-3-oxoprop-1-en-1-yl groups, respectively. It is a potent and selective inhibitor of class II (IIa) histone deacetylase (HDAC II).
Synonyms:exact_synonym: 3-{5-[3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl]-1-methyl-1H-pyrrol-2-yl}-N-hydroxyacrylamide
 related_synonym: Formula=C17H15FN2O3;   InChI=1S/C17H15FN2O3/c1-20-14(5-6-15(20)8-10-17(22)19-23)7-9-16(21)12-3-2-4-13(18)11-12/h2-11,23H,1H3,(H,19,22);   InChIKey=QQDIFLSJMFDTCQ-UHFFFAOYSA-N;   MC-1568;   SMILES=N1(C(=CC=C1C(=C(C(C2=CC(=CC=C2)F)=O)[H])[H])C(=C(C(=O)NO)[H])[H])C
 xref: CAS:852475-26-4 "SUBMITTER"
 xref_mesh: MESH:C577554
 xref: PMID:15857140 "Europe PMC";   PMID:23176534 "Europe PMC";   PMID:24450497 "Europe PMC";   PMID:27103167 "Europe PMC";   PMID:27660204 "Europe PMC";   PMID:27739328 "Europe PMC";   PMID:28732762 "Europe PMC";   PMID:29401190 "Europe PMC";   PMID:29412739 "Europe PMC";   PMID:29482060 "Europe PMC";   Reaxys:26700969 "Reaxys"


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MC1568 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cd69 Cd69 molecule JBrowse link 4 163,041,147 163,049,065 RGD:6480464
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ngb neuroglobin JBrowse link 6 111,126,259 111,131,699 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Sp3 Sp3 transcription factor JBrowse link 3 59,644,579 59,689,011 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    chemical entity 19726
      atom 19724
        nonmetal atom 19597
          carbon atom 19494
            organic molecular entity 19494
              olefinic compound 14421
                enone 8408
                  MC1568 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                hydroxamic acid 6248
                                                  MC1568 10
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