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Term:16,16-dimethylprostaglandin E2
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Accession:CHEBI:141046 term browser browse the term
Definition:A prostanoid that is prostaglandin E2 in which both of the hydrogens at position 16 have been replaced by methyl groups. A synthetic analogue of prostaglandin E2, it is a potent inhibitor of pancreatic function and growth of experimental tumors. It also protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers.
Synonyms:exact_synonym: (5Z,11alpha,13E,15R)-11,15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1-oic acid
 related_synonym: 16,16-Dimethyl-pge2;   16,16-Dimethyl-prostaglandin E2;   9-oxo-11R,15R-dihydroxy-16,16-dimethyl-5Z,13E-prostadienoic acid;   Formula=C22H36O5;   InChI=1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,19-,20-/m1/s1;   InChIKey=QAOBBBBDJSWHMU-WMBBNPMCSA-N;   SMILES=C(\\[C@H]1[C@@H](CC([C@@H]1C/C=C\\CCCC(O)=O)=O)O)=C/[C@H](C(CCCC)(C)C)O;   dmPGE(2);   dmPGE2
 xref: CAS:39746-25-3 "ChemIDplus";   LIPID_MAPS_instance:LMFA03010065 "LIPID MAPS"
 xref_mesh: MESH:D015064
 xref: PMID:10630489 "Europe PMC";   PMID:10669047 "Europe PMC";   PMID:10952078 "Europe PMC";   PMID:11208431 "Europe PMC";   PMID:11991626 "Europe PMC";   PMID:1372575 "Europe PMC";   PMID:1373359 "Europe PMC";   PMID:1604570 "Europe PMC";   PMID:1629578 "Europe PMC";   PMID:174967 "Europe PMC";   PMID:19059888 "Europe PMC";   PMID:2116342 "Europe PMC";   PMID:23996087 "Europe PMC";   PMID:3562785 "Europe PMC";   PMID:7201834 "Europe PMC";   PMID:7513369 "Europe PMC";   PMID:7616483 "Europe PMC";   PMID:7625885 "Europe PMC";   PMID:7847837 "Europe PMC";   PMID:7874263 "Europe PMC";   PMID:8225563 "Europe PMC";   PMID:8322025 "Europe PMC";   PMID:8419232 "Europe PMC";   PMID:8514255 "Europe PMC";   PMID:8613460 "Europe PMC";   PMID:9073153 "Europe PMC";   PMID:9481403 "Europe PMC"

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16,16-dimethylprostaglandin E2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Hpgd 15-hydroxyprostaglandin dehydrogenase JBrowse link 16 37,457,134 37,495,758 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      application 19308
        pharmaceutical 19179
          drug 19179
            anti-ulcer drug 750
              16,16-dimethylprostaglandin E2 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        monocarboxylic acid 17260
                                          fatty acid 15814
                                            fatty acid derivative 1017
                                              icosanoid 451
                                                prostanoid 394
                                                  16,16-dimethylprostaglandin E2 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.