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Accession:CHEBI:141346 term browser browse the term
Definition:A carboxybiphenyl that is [biphenyl]-3-carboxylic acid carrying a (2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)nitrilo group at the 3' position. A selective beta3-adrenergic receptor agonist currently in clinical development for the treatment of overactive bladder and irritable bowel syndrome.
Synonyms:exact_synonym: 3'-[(2-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino][biphenyl]-3-carboxylic acid
 related_synonym: (R)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic acid;   Formula=C23H23ClN2O3;   GW-427353;   GW427353;   InChI=1S/C23H23ClN2O3/c24-20-8-2-6-18(13-20)22(27)15-25-10-11-26-21-9-3-5-17(14-21)16-4-1-7-19(12-16)23(28)29/h1-9,12-14,22,25-27H,10-11,15H2,(H,28,29)/t22-/m0/s1;   InChIKey=LLDXOPKUNJTIRF-QFIPXVFZSA-N;   SMILES=C=1C(=CC=CC1Cl)[C@H](CNCCNC=2C=C(C=CC2)C=3C=CC=C(C3)C(=O)O)O;   solabegronum
 xref: CAS:252920-94-8 "ChemIDplus";   DrugBank:DB06190
 xref_mesh: MESH:C523977
 xref: PMID:16640337 "Europe PMC";   PMID:17026593 "Europe PMC";   PMID:17626794 "Europe PMC";   PMID:18372395 "Europe PMC";   PMID:19786030 "Europe PMC";   PMID:22695239 "Europe PMC";   PMID:25557359 "Europe PMC";   PMID:25689345 "Europe PMC";   PMID:26954275 "Europe PMC";   Patent:US8642661;   Reaxys:10484931 "Reaxys";   Wikipedia:Solabegron

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solabegron term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb3 adrenoceptor beta 3 JBrowse link 16 69,003,541 69,006,632 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      application 19336
        refrigerant 17097
          ammonia 16696
            organic amino compound 16695
              secondary amino compound 6383
                solabegron 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        aromatic carboxylic acid 10743
                                          benzoic acids 10709
                                            carboxybiphenyl 99
                                              solabegron 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.