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ONTOLOGY REPORT - ANNOTATIONS


Term:imidaprilat
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Accession:CHEBI:141520 term browser browse the term
Definition:A member of the class of imidazolidines that is imidapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of imidapril used to treat hypertension.
Synonyms:exact_synonym: (4S)-3-{N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl}-1-methyl-2-oxoimidazolidine-4-carboxylic acid
 related_synonym: (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid;   Formula=C18H23N3O6;   InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1;   InChIKey=VFAVNRVDTAPBNR-UBHSHLNASA-N;   SMILES=C1=CC=CC(=C1)CC[C@H](N[C@H](C(N2C(N(C[C@H]2C(O)=O)C)=O)=O)C)C(=O)O;   imidaprilate;   imidaprilatum
 xref: CAS:89371-44-8 "ChemIDplus";   KEGG:C21519
 xref_mesh: MESH:C078006
 xref: PMID:11089901 "Europe PMC";   PMID:16406270 "Europe PMC";   PMID:18192036 "Europe PMC";   PMID:8923331 "Europe PMC";   PMID:9278890 "Europe PMC";   PMID:9591932 "Europe PMC";   Reaxys:5857382 "Reaxys"


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imidaprilat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pro-agent 8807
          prodrug 8597
            imidapril 4
              imidaprilat 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  urea 4949
                                                    ureas 4946
                                                      N-acylurea 25
                                                        imidapril 4
                                                          imidaprilat 2
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