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ONTOLOGY REPORT - ANNOTATIONS


Term:trisodium phosphonoformate
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Accession:CHEBI:141644 term browser browse the term
Definition:The trisodium salt of phosphonoformic acid. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Synonyms:related_synonym: FOSCARNET SODIUM;   Formula=CNa3O5P;   InChI=1S/CH3O5P.3Na/c2-1(3)7(4,5)6;;;/h(H,2,3)(H2,4,5,6);;;/q;3*+1/p-3;   InChIKey=DFHAXXVZCFXGOQ-UHFFFAOYSA-K;   SMILES=[Na+].[Na+].[Na+].[O-]C(=O)P([O-])([O-])=O;   foscarnet sodique;   foscarneto sodico;   foscarnetum natricum;   trisodium carboxyphosphate;   trisodium carboxyphosphate (anhydrous);   trisodium dioxidophosphinecarboxylate oxide;   trisodium phosphonoformate (anhydrous)
 alt_id: CHEBI:5161
 xref: CAS:63585-09-1 "ChemIDplus";   CAS:63585-09-1 "KEGG DRUG";   DrugBank:DB00529;   KEGG:D00579


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  CHEBI ontology 19654
    role 19598
      biological role 19596
        antimicrobial agent 17143
          antiviral agent 3604
            antiviral drug 1646
              trisodium phosphonoformate 0
                trisodium phosphonoformate hexahydrate 0
Path 2
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  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    main group molecular entity 19531
                      s-block molecular entity 19314
                        alkali metal molecular entity 9963
                          sodium molecular entity 7781
                            elemental sodium 7781
                              sodium(1+) 7781
                                sodium salt 7781
                                  organic sodium salt 301
                                    trisodium phosphonoformate 0
                                      trisodium phosphonoformate hexahydrate 0
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