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ONTOLOGY REPORT - ANNOTATIONS


Term:cinaciguat
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Accession:CHEBI:142433 term browser browse the term
Definition:A benzoic acid that is 4-(aminomethyl)benzoic acid in which the amino group is substituted by 4-carboxybutyl and 2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl groups. It is a soluble guanylate cyclase activator, used for the treatment of acute decompensated heart failure.
Synonyms:exact_synonym: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid
 related_synonym: BAY 58-2667;   BAY582667;   Formula=C36H39NO5;   InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41);   InChIKey=WPYWMXNXEZFMAK-UHFFFAOYSA-N;   SMILES=C=1C=CC=C(C1)CCC2=CC=C(C=C2)COC3=C(C=CC=C3)CCN(CCCCC(O)=O)CC4=CC=C(C=C4)C(O)=O;   cinaciguatum
 xref: CAS:329773-35-5 "ChemIDplus";   CAS:329773-35-5 "KEGG DRUG";   KEGG:D07577
 xref_mesh: MESH:C480588
 xref: PDBeChem:Z90;   PMID:18779378 "Europe PMC";   PMID:20067336 "Europe PMC";   PMID:20463019 "Europe PMC";   PMID:20730699 "Europe PMC";   PMID:21856817 "Europe PMC";   PMID:21868716 "Europe PMC";   PMID:22474005 "Europe PMC";   PMID:22713287 "Europe PMC";   PMID:23144773 "Europe PMC";   PMID:24090476 "Europe PMC";   PMID:25200007 "Europe PMC";   PMID:26520063 "Europe PMC";   PMID:27122537 "Europe PMC";   PMID:27853261 "Europe PMC";   PMID:28894114 "Europe PMC";   PMID:29138269 "Europe PMC";   PMID:29653192 "Europe PMC";   Patent:US2012010292;   Reaxys:9676935 "Reaxys";   Wikipedia:Cinaciguat


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cinaciguat term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 JBrowse link 2 181,045,694 181,103,321 RGD:6480464
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 2 180,976,939 181,026,001 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        biochemical role 19190
          effector 102
            soluble guanylate cyclase activator 6
              cinaciguat 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        aromatic carboxylic acid 10724
                                          benzoic acids 10690
                                            cinaciguat 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.