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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triacsin C
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Accession:CHEBI:144441 term browser browse the term
Definition:A nitroso compound that is N-undecylnitrous hydrazide carrying double bonds at positions 1,2,4, and 7. It is a long-chain fatty acyl CoA synthetase inhibitor and interferes with lipid metabolism by inhibiting the de novo synthesis of glycerolipids and cholesterol esters.
Synonyms:exact_synonym: N-[(1E,2E,4E,7E)-undeca-2,4,7-trien-1-ylidene]nitrous hydrazide
 related_synonym: (2E,4E,7E)-2,4,7-undecatrienal nitrosohydrazone;   2,4,7-undecatrienal nitrosohydrazone;   FR 900190;   Formula=C11H17N3O;   InChI=1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+;   InChIKey=NKTGCVUIESDXPU-YLEPRARLSA-N;   SMILES=C(/C=C/C=C/C/C=C/CCC)=N\\NN=O;   WS 1228A;   nitrosohydrazone-2E,4E,7E-undecatrienal
 xref: CAS:76896-80-5;   LINCS:LSM-43284
 xref_mesh: MESH:C034613
 xref: MetaCyc:CPD-14770;   PMID:15249192;   PMID:17446697;   PMID:18653998;   PMID:1999415;   PMID:23565210;   PMID:26719343;   PMID:28918598;   PMID:3117118;   PMID:6804425;   PMID:6804426;   PMID:9182714;   Wikipedia:Triacsin_C


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triacsin C term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO triacsin C inhibits the reaction [Fatty Acids results in increased degradation of ABCA1 protein]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]]; triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein] CTD PMID:16118212 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO triacsin C results in decreased expression of ABCD3 mRNA CTD PMID:16704987 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein] CTD PMID:18390901 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression ISO triacsin C results in decreased expression of ADARB1 mRNA CTD PMID:16704987 NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression ISO triacsin C results in decreased expression of AQP3 mRNA CTD PMID:16704987 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO triacsin C results in increased expression of ARHGDIA mRNA CTD PMID:16704987 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO triacsin C results in increased expression of ATF3 mRNA CTD PMID:16704987 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression ISO triacsin C results in decreased expression of BDNF mRNA CTD PMID:16704987 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 increases activity ISO triacsin C results in increased activity of CASP3 protein CTD PMID:16704987 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain decreases expression ISO triacsin C results in decreased expression of COL18A1 mRNA CTD PMID:16704987 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Ctdspl CTD small phosphatase like decreases expression ISO triacsin C results in decreased expression of CTDSPL mRNA CTD PMID:16704987 NCBI chr 8:127,065,292...127,726,248
Ensembl chr 8:127,702,534...127,726,127
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO triacsin C results in increased expression of DDIT4 mRNA CTD PMID:16704987 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx24 DEAD-box helicase 24 decreases expression ISO triacsin C results in decreased expression of DDX24 mRNA CTD PMID:16704987 NCBI chr 6:127,302,201...127,319,382
Ensembl chr 6:127,302,201...127,319,362
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO triacsin C results in decreased expression of DHCR7 mRNA CTD PMID:16704987 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression ISO triacsin C results in decreased expression of EBP mRNA CTD PMID:16704987 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Egr1 early growth response 1 increases expression ISO triacsin C results in increased expression of EGR1 mRNA CTD PMID:16704987 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog decreases expression ISO triacsin C results in decreased expression of ERG28 mRNA CTD PMID:16704987 NCBI chr 6:109,683,252...109,692,218
Ensembl chr 6:109,683,253...109,692,218
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO triacsin C results in decreased expression of FGFR3 mRNA CTD PMID:16704987 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO triacsin C results in increased expression of FOS mRNA CTD PMID:16704987 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO triacsin C results in increased expression of FOSL1 mRNA CTD PMID:16704987 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO triacsin C results in increased expression of GCLC mRNA CTD PMID:16704987 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO triacsin C results in increased expression of GCLM mRNA CTD PMID:16704987 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gnpda1 glucosamine-6-phosphate deaminase 1 decreases expression ISO triacsin C results in decreased expression of GNPDA1 mRNA CTD PMID:16704987 NCBI chr18:31,479,117...31,489,154
Ensembl chr18:31,479,117...31,487,671
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO triacsin C results in decreased expression of HMGCR mRNA CTD PMID:16704987 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO triacsin C results in increased expression of HMOX1 mRNA CTD PMID:16704987 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hs2st1 heparan sulfate 2-O-sulfotransferase 1 decreases expression ISO triacsin C results in decreased expression of HS2ST1 mRNA CTD PMID:16704987 NCBI chr 2:250,467,428...250,600,517
Ensembl chr 2:250,467,429...250,600,517
JBrowse link
G Hspb11 heat shock protein family B (small), member 11 decreases expression ISO triacsin C results in decreased expression of HSPB11 mRNA CTD PMID:16704987 NCBI chr 5:126,856,128...126,882,913
Ensembl chr 5:126,856,705...126,882,909
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO triacsin C results in decreased expression of ID3 mRNA CTD PMID:16704987 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO triacsin C results in decreased expression of IDI1 mRNA CTD PMID:16704987 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 decreases expression ISO triacsin C results in decreased expression of IGFBP7 mRNA CTD PMID:16704987 NCBI chr14:33,010,300...33,070,193
Ensembl chr14:33,010,300...33,070,190
JBrowse link
G Ilvbl ilvB acetolactate synthase like decreases expression ISO triacsin C results in decreased expression of ILVBL mRNA CTD PMID:16704987 NCBI chr 7:14,044,586...14,054,639
Ensembl chr 7:14,044,586...14,054,639
JBrowse link
G Isl1 ISL LIM homeobox 1 decreases expression ISO triacsin C results in decreased expression of ISL1 mRNA CTD PMID:16704987 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Itga6 integrin subunit alpha 6 increases expression ISO triacsin C results in increased expression of ITGA6 mRNA CTD PMID:16704987 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO triacsin C results in increased expression of and results in increased phosphorylation of JUN protein
triacsin C results in increased expression of JUN mRNA
CTD PMID:16704987 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO triacsin C results in increased expression of KLF5 mRNA CTD PMID:16704987 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Lss lanosterol synthase decreases expression ISO triacsin C results in decreased expression of LSS mRNA CTD PMID:16704987 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Luc7l3 LUC7-like 3 pre-mRNA splicing factor decreases expression ISO triacsin C results in decreased expression of LUC7L3 mRNA CTD PMID:16704987 NCBI chr10:81,991,147...82,027,119
Ensembl chr10:81,991,147...82,027,119
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO triacsin C results in increased expression of MAFF mRNA CTD PMID:16704987 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Nr2f1 nuclear receptor subfamily 2, group F, member 1 decreases expression ISO triacsin C results in decreased expression of NR2F1 mRNA CTD PMID:16704987 NCBI chr 2:5,569,954...5,579,894
Ensembl chr 2:5,569,935...5,579,894
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression ISO triacsin C results in decreased expression of NR4A2 mRNA CTD PMID:16704987 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nrtn neurturin decreases expression ISO triacsin C results in decreased expression of NRTN mRNA CTD PMID:16704987 NCBI chr 9:10,299,881...10,306,599
Ensembl chr 9:10,305,470...10,306,597
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein decreases expression ISO triacsin C results in decreased expression of PDE4DIP mRNA CTD PMID:16704987 NCBI chr 2:199,867,965...200,066,034
Ensembl chr 2:199,867,972...200,003,443
JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 decreases expression ISO triacsin C results in decreased expression of PDSS2 mRNA CTD PMID:16704987 NCBI chr20:47,966,513...48,192,747
Ensembl chr20:47,966,583...48,192,743
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO triacsin C results in increased expression of PHLDA1 mRNA CTD PMID:16704987 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO triacsin C results in increased expression of PMAIP1 mRNA CTD PMID:16704987 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein] CTD PMID:18390901 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prpf4 pre-mRNA processing factor 4 decreases expression ISO triacsin C results in decreased expression of PRPF4 mRNA CTD PMID:16704987 NCBI chr 5:78,267,248...78,281,172
Ensembl chr 5:78,267,248...78,281,172
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO triacsin C results in increased expression of PSAT1 mRNA CTD PMID:16704987 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression ISO triacsin C results in increased expression of PTP4A1 mRNA CTD PMID:16704987 NCBI chr 9:37,223,363...37,254,222
Ensembl chr 9:37,223,729...37,231,291
JBrowse link
G Rapgef2 Rap guanine nucleotide exchange factor 2 increases expression ISO triacsin C results in increased expression of RAPGEF2 mRNA CTD PMID:16704987 NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO triacsin C results in decreased expression of SKP2 mRNA CTD PMID:16704987 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO triacsin C results in increased expression of SLC7A11 mRNA CTD PMID:16704987 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO triacsin C results in increased expression of SNAI2 mRNA CTD PMID:16704987 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO triacsin C results in decreased expression of SOX9 mRNA CTD PMID:16704987 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression ISO triacsin C results in decreased expression of SPARC mRNA CTD PMID:16704987 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Spast spastin decreases expression ISO triacsin C results in decreased expression of SPAST mRNA CTD PMID:16704987 NCBI chr 6:22,230,067...22,282,166
Ensembl chr 6:22,230,928...22,281,886
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO triacsin C results in increased expression of SQSTM1 mRNA CTD PMID:16704987 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 decreases expression ISO triacsin C results in decreased expression of SRGAP2 mRNA CTD PMID:16704987 NCBI chr13:48,065,280...48,286,888
Ensembl chr13:48,068,158...48,286,720
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO triacsin C results in increased expression of STC2 mRNA CTD PMID:16704987 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression ISO triacsin C results in increased expression of TNFRSF12A mRNA CTD PMID:16704987 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Tns3 tensin 3 decreases expression ISO triacsin C results in decreased expression of TNS3 mRNA CTD PMID:16704987 NCBI chr14:88,673,922...88,907,874
Ensembl chr14:88,673,881...88,886,198
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression ISO triacsin C results in decreased expression of TOP2A mRNA CTD PMID:16704987 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Ucp3 uncoupling protein 3 increases expression ISO triacsin C results in increased expression of UCP3 mRNA CTD PMID:11056218 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta increases expression ISO triacsin C results in increased expression of YWHAZ mRNA CTD PMID:16704987 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        inhibitor 18247
          apoptosis inhibitor 6788
            triacsin C 64
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon group molecular entity 19608
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organonitrogen compound 18338
                                hydrazone 535
                                  triacsin C 64
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.