Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:SB-245391
go back to main search page
Accession:CHEBI:144676 term browser browse the term
Definition:A piperidinylimidazole that is 1H-imidazole carrying a piperidin-4-yl group, 4-fluorophenyl group and a 2-([biphenyl]-4-yloxy)pyrimidin-4-yl group at positions 1, 4 and 5 respectively. It is a potent inhibitor of p38alpha mitogen-activated protein kinase.
Synonyms:exact_synonym: 2-([biphenyl]-4-yloxy)-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidine
 related_synonym: 2-(4-biphenylyloxy)-4-[1-(piperidine-4-yl)-4-(4-fluorophenyl)-5-imidazolyl]pyrimidine;   2-[([1,1'-biphenyl]-4-yl)oxy]-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidine;   Formula=C30H26FN5O;   InChI=1S/C30H26FN5O/c31-24-10-6-23(7-11-24)28-29(36(20-34-28)25-14-17-32-18-15-25)27-16-19-33-30(35-27)37-26-12-8-22(9-13-26)21-4-2-1-3-5-21/h1-13,16,19-20,25,32H,14-15,17-18H2;   InChIKey=WHARNYOKNQYQGR-UHFFFAOYSA-N;   SMILES=C1(=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCNCC4)=N1)OC=5C=CC(=CC5)C=6C=CC=CC6
 xref: PMID:11354358


show annotations for term's descendants       view all columns           Sort by:
 

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21260
    chemical entity 21258
      molecular entity 21251
        polyatomic entity 21130
          molecule 20685
            cyclic compound 20128
              ring assembly 7311
                biphenyls 6049
                  SB-245391 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21125
                    p-block element atom 21125
                      carbon group element atom 20894
                        carbon atom 20785
                          organic molecular entity 20785
                            organic molecule 20668
                              organic cyclic compound 20127
                                organic heterocyclic compound 19011
                                  heteroarene 15973
                                    monocyclic heteroarene 13302
                                      azole 12542
                                        diazole 8251
                                          imidazoles 7757
                                            piperidinylimidazole 0
                                              SB-245391 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.