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ONTOLOGY REPORT - ANNOTATIONS


Term:epoxy steroid
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Accession:CHEBI:145217 term browser browse the term
Definition:Any steroid whose structure includes an epoxy group.
Synonyms:related_synonym: epoxy-steroids


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5,6alpha-epoxy-5alpha-cholestan-3beta-ol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Ephx1 epoxide hydrolase 1 JBrowse link 13 99,271,390 99,300,580 RGD:6480464
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
eplerenone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6480464
G Col4a1 collagen type IV alpha 1 chain JBrowse link 16 83,522,162 83,632,153 RGD:6480464
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6480464
G Osr1 odd-skipped related transcription factor 1 JBrowse link 6 35,314,431 35,321,458 RGD:6480464
G Oxsr1 oxidative stress responsive kinase 1 JBrowse link 8 127,920,349 128,009,951 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Slc12a3 solute carrier family 12 member 3 JBrowse link 19 11,106,033 11,144,674 RGD:6480464
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:6480464
G Snai1 snail family transcriptional repressor 1 JBrowse link 3 164,274,710 164,279,199 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Stk39 serine threonine kinase 39 JBrowse link 3 54,359,449 54,625,702 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tgfbi transforming growth factor, beta induced JBrowse link 17 8,400,123 8,429,338 RGD:6480464
trilostane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Fgf9 fibroblast growth factor 9 JBrowse link 15 38,341,657 38,386,945 RGD:6480464
G Fshb follicle stimulating hormone subunit beta JBrowse link 3 98,088,321 98,092,131 RGD:6480464
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:6480464
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 JBrowse link 2 200,756,557 200,762,492 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:6480464
withaferin A term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:6480464
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2a1 BCL2-related protein A1 JBrowse link 8 96,551,424 96,559,527 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cdkn2aip CDKN2A interacting protein JBrowse link 16 47,664,864 47,670,935 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6480464
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:6480464
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:6480464
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:6480464
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:6480464
G Ezr ezrin JBrowse link 1 47,287,872 47,331,412 RGD:6480464
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6480464
G Hnrnpk heterogeneous nuclear ribonucleoprotein K JBrowse link 17 6,664,730 6,676,753 RGD:6480464
G Hspa9 heat shock protein family A (Hsp70) member 9 JBrowse link 18 27,731,072 27,749,235 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mecp2 methyl CpG binding protein 2 JBrowse link X 156,650,389 156,713,813 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Procr protein C receptor JBrowse link 3 151,285,321 151,289,581 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464
G Tubb5 tubulin, beta 5 class I JBrowse link 20 3,422,448 3,426,420 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    chemical entity 19726
      molecular entity 19723
        main group molecular entity 19610
          gas molecular entity 17243
            oxirane 5315
              epoxide 5313
                epoxy steroid 81
                  (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                  (24S,25)-epoxy-7alpha-hydroxycholesterol 0
                  (3beta,24R,24'R)-fucosterol epoxide 0
                  17alpha-hydroxywithanolide D 0
                  2,3-dihydro-3beta-O-sulfate withaferin A 0
                  2,3-dihydro-3beta-methoxy withaferin A 0
                  2,3-dihydrowithaferin A 0
                  20-hydroxytubocapsanolide A 0
                  23-hydroxytubocapsanolide A 0
                  24(S),25-epoxycholesterol 0
                  3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + 0
                  3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                  5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                  5,6alpha-epoxy-5alpha-cholestane 0
                  5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                  7-deacetyl-7-benzoylepoxyazadiradione 0
                  9,11alpha-epoxypregn-4-ene-3,20-dione 0
                  cholestanol 7alpha,8alpha-epoxide 0
                  cholesterol beta-epoxide 0
                  deacetyltanghinin 0
                  eplerenone 24
                  physalin F 0
                  sitoindoside IX 0
                  tanghinigenin + 0
                  trilostane 10
                  tubocapsanolide A + 0
                  tubocapsanolide F 0
                  viscosalactone B 0
                  withaferin A + 45
                  withalongolide A 0
                  withalongolide B 0
                  withalongolide C 0
                  withalongolide D 0
                  withalongolide E 0
                  withalongolide G 0
                  withalongolide H 0
                  withanolide D + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic molecule 19417
                              organic cyclic compound 19184
                                organic heterocyclic compound 18262
                                  organic heteromonocyclic compound 16347
                                    saturated organic heteromonocyclic parent 5354
                                      oxirane 5315
                                        epoxide 5313
                                          epoxy steroid 81
                                            (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                                            (24S,25)-epoxy-7alpha-hydroxycholesterol 0
                                            (3beta,24R,24'R)-fucosterol epoxide 0
                                            17alpha-hydroxywithanolide D 0
                                            2,3-dihydro-3beta-O-sulfate withaferin A 0
                                            2,3-dihydro-3beta-methoxy withaferin A 0
                                            2,3-dihydrowithaferin A 0
                                            20-hydroxytubocapsanolide A 0
                                            23-hydroxytubocapsanolide A 0
                                            24(S),25-epoxycholesterol 0
                                            3beta-hydroxy-16alpha,17alpha-epoxypregnenolone + 0
                                            3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 0
                                            5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                                            5,6alpha-epoxy-5alpha-cholestane 0
                                            5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                                            7-deacetyl-7-benzoylepoxyazadiradione 0
                                            9,11alpha-epoxypregn-4-ene-3,20-dione 0
                                            cholestanol 7alpha,8alpha-epoxide 0
                                            cholesterol beta-epoxide 0
                                            deacetyltanghinin 0
                                            eplerenone 24
                                            physalin F 0
                                            sitoindoside IX 0
                                            tanghinigenin + 0
                                            trilostane 10
                                            tubocapsanolide A + 0
                                            tubocapsanolide F 0
                                            viscosalactone B 0
                                            withaferin A + 45
                                            withalongolide A 0
                                            withalongolide B 0
                                            withalongolide C 0
                                            withalongolide D 0
                                            withalongolide E 0
                                            withalongolide G 0
                                            withalongolide H 0
                                            withanolide D + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.