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ONTOLOGY REPORT - ANNOTATIONS


Term:O-desethyl candesartan
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Accession:CHEBI:145224 term browser browse the term
Definition:A benzimidazolecarboxylic acid that is candesartan in which the ethoxy group has been replaced by a hydroxy group. It is the inactive metabolite of the anti-hypertensive drug, candesartan.
Synonyms:exact_synonym: 2-oxo-3-{[2'-(1H-tetrazol-5-yl)[biphenyl]-4-yl]methyl}-2,3-dihydro-1H-benzimidazole-4-carboxylic acid
 related_synonym: CV 15959;   Formula=C22H16N6O3;   InChI=1S/C22H16N6O3/c29-21(30)17-6-3-7-18-19(17)28(22(31)23-18)12-13-8-10-14(11-9-13)15-4-1-2-5-16(15)20-24-26-27-25-20/h1-11H,12H2,(H,23,31)(H,29,30)(H,24,25,26,27);   InChIKey=KLCPKPIDOPBIQW-UHFFFAOYSA-N;   O-deethylated candesartan;   SMILES=C1(=CC=C(C=C1)CN2C3=C(C(=O)O)C=CC=C3NC2=O)C=4C=CC=CC4C5=NN=NN5
 xref: CAS:168434-02-4 "ChemIDplus";   HMDB:HMDB0013842;   PMID:10383542 "Europe PMC";   PMID:10510797 "Europe PMC";   PMID:11825094 "Europe PMC";   PMID:8548019 "Europe PMC";   PMID:9331000 "Europe PMC";   PMID:9331004 "Europe PMC"


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  CHEBI ontology 19734
    role 19680
      biological role 19678
        biochemical role 19177
          metabolite 19147
            xenobiotic metabolite 13835
              human xenobiotic metabolite 13025
                drug metabolite 4394
                  O-desethyl candesartan 0
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  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        monocarboxylic acid 17265
                                          benzimidazolecarboxylic acid 73
                                            O-desethyl candesartan 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.