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Accession:CHEBI:145331 term browser browse the term
Definition:An imidazobenzodiazepine that is midazolam which is substituted by a hydroxy group at position 4. It is the minor hydroxylated metabolite of the anesthetic, midazolam.
Synonyms:exact_synonym: 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol
 related_synonym: 4-OH midazolam;   4-OH-MDZ;   Formula=C18H13ClFN3O;   InChI=1S/C18H13ClFN3O/c1-10-21-9-16-18(24)22-17(12-4-2-3-5-14(12)20)13-8-11(19)6-7-15(13)23(10)16/h2-9,18,24H,1H3;   InChIKey=ZYISITHKPKHPKG-UHFFFAOYSA-N;   Ro 21-5975;   SMILES=C1(=NC(C=2N(C=3C1=CC(=CC3)Cl)C(=NC2)C)O)C=4C=CC=CC4F
 xref: CAS:59468-85-8 "ChemIDplus";   CAS:59468-85-8 "NIST Chemistry WebBook";   HMDB:HMDB0061090
 xref_mesh: MESH:C042940
 xref: PMID:15018796 "Europe PMC";   PMID:20434409 "Europe PMC";   PMID:20713656 "Europe PMC";   PMID:21204116 "Europe PMC";   PMID:21992114 "Europe PMC";   PMID:22841553 "Europe PMC";   PMID:23870610 "Europe PMC";   PMID:28978489 "Europe PMC";   PMID:31474719 "Europe PMC";   PMID:9187388 "Europe PMC"

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4-hydroxymidazolam term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      biological role 19678
        biochemical role 19177
          apoptosis inducer 10837
            midazolam 27
              4-hydroxymidazolam 1
                4-hydroxymidazolam beta-D-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic molecule 19418
                              organic cyclic compound 19189
                                carbocyclic compound 17551
                                  benzenoid aromatic compound 17097
                                    benzenes 16828
                                      fluorobenzenes 1621
                                        monofluorobenzenes 1290
                                          midazolam 27
                                            4-hydroxymidazolam 1
                                              4-hydroxymidazolam beta-D-glucuronide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.