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Accession:CHEBI:145373 term browser browse the term
Definition:A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).
Synonyms:exact_synonym: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine
 related_synonym: CML-261;   Formula=C20H15ClF3N5;   InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29);   InChIKey=JGWRKYUXBBNENE-UHFFFAOYSA-N;   PLX-3397;   PLX3397;   SMILES=C1=C(C=C2C(=N1)NC=C2CC3=CN=C(C=C3)NCC4=CC=C(N=C4)C(F)(F)F)Cl;   Turalio;   pexidartinibum
 xref: CAS:1029044-16-3;   DrugBank:DB12978;   KEGG:D11270;   PDBeChem:P31;   PMCID:PMC6012252;   PMID:26222558;   PMID:26449250;   PMID:30002809;   PMID:30628737;   PMID:30825104;   PMID:30926949;   PMID:31167689;   PMID:31213500;   PMID:31229240;   PMID:31240240;   PMID:31258629;   PMID:31602563;   PMID:31696640;   Wikipedia:Pexidartinib

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                          hydrides 18363
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                                  azane 16704
                                    ammonia 16703
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                                        aromatic amine 13622
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