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Accession:CHEBI:145994 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.
Synonyms:exact_synonym: 2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate
 related_synonym: (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester;   2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate;   Formula=C27H35N6O8P;   GS-5734;   GS5734;   InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1;   InChIKey=RWWYLEGWBNMMLJ-YSOARWBDSA-N;   SMILES=[C@]1(O[C@@H]([C@H]([C@H]1O)O)CO[P@@](N[C@H](C(OCC(CC)CC)=O)C)(OC=2C=CC=CC2)=O)(C#N)C=3N4N=CN=C(C4=CC3)N;   remdesivirum
 xref: CAS:1809249-37-3;   DrugBank:DB14761;   KEGG:D11472;   PMCID:PMC5630887;   PMID:26934220;   PMID:28124907;   PMID:28262699;   PMID:28659436;   PMID:29511076;   PMID:30275474;   PMID:30987343;   PMID:31142680;   PMID:31233808;   PMID:31924756;   PMID:32020029;   PMID:32054787;   PMID:32094225;   PMID:32145386;   PMID:32147516;   PMID:32152082;   Wikipedia:Remdesivir

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remdesivir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:30309211
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:30309211
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:30309211
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:30309211
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:30309211

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19778
    role 19725
      application 19370
        pro-agent 8838
          prodrug 8627
            remdesivir 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19778
    subatomic particle 19776
      composite particle 19776
        hadron 19776
          baryon 19776
            nucleon 19776
              atomic nucleus 19776
                atom 19776
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19556
                        carbon atom 19545
                          organic molecular entity 19545
                            heteroorganic entity 19138
                              organochalcogen compound 18836
                                organooxygen compound 18755
                                  carbohydrates and carbohydrate derivatives 12152
                                    carbohydrate 12152
                                      carbohydrate derivative 11776
                                        glycosyl compound 10812
                                          C-glycosyl compound 228
                                            C-nucleoside 5
                                              GS-441524 5
                                                remdesivir 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.