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ONTOLOGY REPORT - ANNOTATIONS


Term:15-acetyldeoxynivalenol
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Accession:CHEBI:146194 term browser browse the term
Definition:A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.
Synonyms:exact_synonym: (12R)-3alpha,7alpha-dihydroxy-8-oxo-12,13-epoxytrichothec-9-en-15-yl acetate
 related_synonym: (3alpha,7alpha)-15-(acetyloxy)-12,13-epoxy-3,7-dihydroxytrichothec-9-en-8-one;   15-(acetyloxy)-12,13-epoxy-3alpha,7alpha-dihydroxytrichothec-9-en-8-one;   15-AcDON;   15-acetyl-DON;   15-acetyl-deoxynivalenol;   Formula=C17H22O7;   InChI=1S/C17H22O7/c1-8-4-11-16(6-22-9(2)18,13(21)12(8)20)15(3)5-10(19)14(24-11)17(15)7-23-17/h4,10-11,13-14,19,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17-/m1/s1;   InChIKey=IDGRYIRJIFKTAN-FWTUUSPJSA-N;   SMILES=C1O[C@@]21[C@]3([C@@]4([C@@](C=C(C)C([C@H]4O)=O)(O[C@@]2([C@H](O)C3)[H])[H])COC(=O)C)C
 xref: AGR:IND20402870;   AGR:IND45257683;   CAS:88337-96-6
 xref_mesh: MESH:C046760
 xref: PMID:11510664;   PMID:18632156;   PMID:19783651;   PMID:21204935;   PMID:22367943;   PMID:22465835;   PMID:22997060;   PMID:23470877;   PMID:23605932;   PMID:24385417;   PMID:25772259;   PMID:26274975;   PMID:26343882;   PMID:27131905;   PMID:27483321;   PMID:29914486;   PMID:30806951;   PMID:3692388


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15-acetyldeoxynivalenol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Angptl4 angiopoietin-like 4 JBrowse link 7 18,627,814 18,634,043 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:6480464
G Areg amphiregulin JBrowse link 14 18,521,921 18,531,179 RGD:6480464
G Arid5a AT-rich interaction domain 5A JBrowse link 9 42,871,907 42,886,725 RGD:6480464
G Arl5b ADP-ribosylation factor like GTPase 5B JBrowse link 17 82,065,893 82,092,693 RGD:6480464
G Arrdc4 arrestin domain containing 4 JBrowse link 1 129,766,097 129,780,076 RGD:6480464
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:6480464
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:6480464
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:6480464
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:6480464
G Bhlhe40 basic helix-loop-helix family, member e40 JBrowse link 4 140,703,619 140,709,319 RGD:6480464
G Btg2 BTG anti-proliferation factor 2 JBrowse link 13 50,913,185 50,916,944 RGD:6480464
G Ccdc116 coiled-coil domain containing 116 JBrowse link 11 88,092,794 88,100,220 RGD:6480464
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Ccl7 C-C motif chemokine ligand 7 JBrowse link 10 69,423,083 69,424,933 RGD:6480464
G Ccr7 C-C motif chemokine receptor 7 JBrowse link 10 87,057,335 87,067,444 RGD:6480464
G Crem cAMP responsive element modulator JBrowse link 17 57,021,704 57,090,888 RGD:6480464
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:6480464
G Dixdc1 DIX domain containing 1 JBrowse link 8 55,091,232 55,164,636 RGD:6480464
G Dlx1 distal-less homeobox 1 JBrowse link 3 58,164,931 58,169,521 RGD:6480464
G Dlx2 distal-less homeobox 2 JBrowse link 3 58,180,088 58,181,971 RGD:6480464
G Dmrt2 doublesex and mab-3 related transcription factor 2 JBrowse link 1 243,662,819 243,669,312 RGD:6480464
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 JBrowse link 5 58,393,197 58,402,162 RGD:6480464
G Dusp10 dual specificity phosphatase 10 JBrowse link 13 104,284,660 104,321,455 RGD:6480464
G Dusp8 dual specificity phosphatase 8 JBrowse link 1 215,030,429 215,043,111 RGD:6480464
G Egr3 early growth response 3 JBrowse link 15 51,756,683 51,762,080 RGD:6480464
G Eif2a eukaryotic translation initiation factor 2A JBrowse link 2 148,722,343 148,755,781 RGD:6480464
G Emx2 empty spiracles homeobox 2 JBrowse link 1 280,633,938 280,640,946 RGD:6480464
G Ephb3 Eph receptor B3 JBrowse link 11 83,527,960 83,546,742 RGD:6480464
G Ereg epiregulin JBrowse link 14 18,577,620 18,591,395 RGD:6480464
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:6480464
G Fam214b family with sequence similarity 214, member B JBrowse link 5 58,477,894 58,484,900 RGD:6480464
G Fam43a family with sequence similarity 43, member A JBrowse link 11 73,676,601 73,679,003 RGD:6480464
G Fbp2 fructose-bisphosphatase 2 JBrowse link 17 372,554 389,918 RGD:6480464
G Fgf9 fibroblast growth factor 9 JBrowse link 15 38,341,657 38,386,945 RGD:6480464
G Fjx1 four-jointed box kinase 1 JBrowse link 3 92,288,818 92,290,919 RGD:6480464
G Gem GTP binding protein overexpressed in skeletal muscle JBrowse link 5 25,339,479 25,353,661 RGD:6480464
G Gfod1 glucose-fructose oxidoreductase domain containing 1 JBrowse link 17 23,818,370 23,924,393 RGD:6480464
G Gtf2ird2 GTF2I repeat domain containing 2 JBrowse link 12 25,509,059 25,555,554 RGD:6480464
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:6480464
G Hoxb2 homeobox B2 JBrowse link 10 84,200,859 84,203,065 RGD:6480464
G Hpse2 heparanase 2 (inactive) JBrowse link 1 262,020,903 263,138,299 RGD:6480464
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:6480464
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Iqcn IQ motif containing N JBrowse link 16 20,467,425 20,483,375 RGD:6480464
G Irgm immunity-related GTPase M JBrowse link 10 34,213,885 34,221,968 RGD:6480464
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 JBrowse link 10 99,429,337 99,442,520 RGD:6480464
G Klf10 Kruppel-like factor 10 JBrowse link 7 77,156,010 77,162,096 RGD:6480464
G Man1b1 mannosidase, alpha, class 1B, member 1 JBrowse link 3 2,547,259 2,569,051 RGD:6480464
G Mfsd2a major facilitator superfamily domain containing 2A JBrowse link 5 140,642,865 140,657,759 RGD:6480464
G Mras muscle RAS oncogene homolog JBrowse link 8 107,629,028 107,656,851 RGD:6480464
G Mxd1 max dimerization protein 1 JBrowse link 4 118,451,752 118,472,150 RGD:6480464
G Neurl3 neuralized E3 ubiquitin protein ligase 3 JBrowse link 9 42,831,737 42,841,765 RGD:6480464
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:6480464
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 JBrowse link 5 63,781,801 63,822,890 RGD:6480464
G Nwd2 NACHT and WD repeat domain containing 2 JBrowse link 14 46,136,780 46,153,320 RGD:6480464
G Pcdh9 protocadherin 9 JBrowse link 15 76,787,108 77,738,668 RGD:6480464
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rcan1 regulator of calcineurin 1 JBrowse link 11 32,539,689 32,620,274 RGD:6480464
G Rem2 RRAD and GEM like GTPase 2 JBrowse link 15 33,121,273 33,125,752 RGD:6480464
G RGD1564664 similar to LOC387763 protein JBrowse link 3 82,854,779 82,856,171 RGD:6480464
G Rgs16 regulator of G-protein signaling 16 JBrowse link 13 71,163,411 71,185,147 RGD:6480464
G Rhoh ras homolog family member H JBrowse link 14 43,961,756 43,992,587 RGD:6480464
G Rnd1 Rho family GTPase 1 JBrowse link 7 140,349,138 140,356,209 RGD:6480464
G Six1 SIX homeobox 1 JBrowse link 6 95,929,060 95,934,296 RGD:6480464
G Slc34a1 solute carrier family 34 member 1 JBrowse link 17 9,747,766 9,762,739 RGD:6480464
G Stmn4 stathmin 4 JBrowse link 15 43,007,901 43,025,852 RGD:6480464
G Stox2 storkhead box 2 JBrowse link 16 47,994,555 48,233,588 RGD:6480464
G Tfap2a transcription factor AP-2 alpha JBrowse link 17 24,653,342 24,670,457 RGD:6480464
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:6480464
G Tmcc2 transmembrane and coiled-coil domain family 2 JBrowse link 13 49,132,685 49,169,771 RGD:6480464
G Tmem88 transmembrane protein 88 JBrowse link 10 55,998,530 56,000,225 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464
G Zbtb21 zinc finger and BTB domain containing 21 JBrowse link 11 38,442,716 38,457,411 RGD:6480464
G Zc3h12d zinc finger CCCH type containing 12D JBrowse link 1 1,937,620 1,972,919 RGD:6480464
G Zfp2 zinc finger protein 2 JBrowse link 10 36,388,136 36,406,721 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19778
    role 19725
      biological role 19724
        epitope 6837
          15-acetyldeoxynivalenol 91
Path 2
Term Annotations click to browse term
  CHEBI ontology 19778
    subatomic particle 19776
      composite particle 19776
        hadron 19776
          baryon 19776
            nucleon 19776
              atomic nucleus 19776
                atom 19776
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19556
                        carbon atom 19545
                          organic molecular entity 19545
                            organic group 18459
                              organic divalent group 18453
                                organodiyl group 18453
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      ketone 15984
                                        oxyketone 8560
                                          alpha-oxyketone 8560
                                            alpha-hydroxy ketone 8560
                                              secondary alpha-hydroxy ketone 868
                                                deoxynivalenol 743
                                                  15-acetyldeoxynivalenol 91
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.