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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Cryptotanshinone
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Accession:CHEBI:149838 term browser browse the term
Synonyms:related_synonym: Formula=C19H20O3;   InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1;   InChIKey=GVKKJJOMQCNPGB-JTQLQIEISA-N;   SMILES=C=1C=C2C(CCCC2(C)C)=C3C1C4=C(C(C3=O)=O)[C@H](CO4)C
 xref: CAS:35825-57-1
 xref_mesh: MESH:C037886


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Cryptotanshinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of ACHE protein CTD PMID:20350537 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of BCHE protein CTD PMID:20350537 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
ISO cryptotanshinone results in increased cleavage of CASP3 protein
cryptotanshinone results in increased activity of CASP3 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [cryptotanshinone results in increased cleavage of CASP3 protein]
CTD PMID:26564229, PMID:28600121 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO cryptotanshinone results in increased activity of CASP7 protein CTD PMID:26564229 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases activity ISO cryptotanshinone results in increased activity of CASP9 protein CTD PMID:26564229 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein] CTD PMID:30208247 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein] CTD PMID:30208247 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]
cryptotanshinone results in increased expression of CYP1A1 mRNA; cryptotanshinone results in increased expression of CYP1A1 protein
CTD PMID:21262253 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO cryptotanshinone results in increased expression of CYP1A2 mRNA; cryptotanshinone results in increased expression of CYP1A2 protein
cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]
CTD PMID:21262253 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form] CTD PMID:30208247 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein] CTD PMID:30208247 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog promotes the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein] CTD PMID:28600121 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:28600121 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO cryptotanshinone results in increased activity of NR1I2 protein CTD PMID:18805405 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cryptotanshinone results in increased cleavage of PARP1 protein CTD PMID:26564229 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein] CTD PMID:30208247 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein] CTD PMID:30208247 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO cryptotanshinone results in decreased activity of PTPN1 protein CTD PMID:29031618 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229, PMID:28600121 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein] CTD PMID:28600121 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO cryptotanshinone results in decreased expression of TOP2A mRNA
cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein
CTD PMID:28716507 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO cryptotanshinone results in decreased expression of TOP2B mRNA CTD PMID:28716507 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        antimicrobial agent 17297
          antiviral agent 10245
            anticoronaviral agent 8938
              Cryptotanshinone 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    main group molecular entity 19655
                      s-block molecular entity 19397
                        hydrogen molecular entity 19387
                          hydrides 18419
                            organic hydride 17728
                              organic fundamental parent 17728
                                hydrocarbon 17241
                                  terpene 9498
                                    terpenoid 9493
                                      diterpenoid 8320
                                        abietane diterpenoid 191
                                          Cryptotanshinone 24
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.