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ONTOLOGY REPORT - ANNOTATIONS


Term:protoporphyrin
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Accession:CHEBI:15430 term browser browse the term
Definition:A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Synonyms:exact_synonym: 7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoic acid
 related_synonym: 3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid;   3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoic acid;   Formula=C34H34N4O4;   H2ppIX;   InChI=1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;   InChIKey=KSFOVUSSGSKXFI-UJJXFSCMSA-N;   Kammerer's prophyrin;   Porphyrinogen IX;   Protoporphyrin IX;   SMILES=Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O;   ooporphyrin
 alt_id: CHEBI:14959;   CHEBI:14960;   CHEBI:14961;   CHEBI:26358;   CHEBI:8592
 xref: Beilstein:635160 "Beilstein";   Beilstein:635161 "Beilstein";   CAS:553-12-8 "ChemIDplus";   CAS:553-12-8 "KEGG COMPOUND";   CAS:553-12-8 "NIST Chemistry WebBook";   DrugBank:DB02285;   Drug_Central:3500 "DrugCentral";   Gmelin:251232 "Gmelin";   HMDB:HMDB0000241;   KEGG:C02191;   KNApSAcK:C00007370
 xref_mesh: MESH:C028025
 xref: MetaCyc:PROTOPORPHYRIN_IX;   PDBeChem:PP9;   PMID:18625294 "Europe PMC";   PMID:19005892 "Europe PMC";   PMID:20961864 "Europe PMC";   PMID:21146529 "Europe PMC";   PMID:21167148 "Europe PMC";   PMID:21668870 "Europe PMC";   PMID:21760730 "Europe PMC";   PMID:21913427 "Europe PMC";   PMID:23533060 "Europe PMC";   Reaxys:380795 "Reaxys";   Wikipedia:Protoporphyrin_IX
 cyclic_relationship: is_conjugate_acid_of CHEBI:36159;   is_conjugate_acid_of CHEBI:57306


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protoporphyrin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6480464
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 JBrowse link 2 181,045,694 181,103,321 RGD:6480464
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 2 180,976,939 181,026,001 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:6480464
G Vcam1 vascular cell adhesion molecule 1 JBrowse link 2 219,071,193 219,090,931 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          metabolite 19106
            protoporphyrin 25
              hematoporphyrin 0
              protoporphyrin monomethyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organonitrogen heterocyclic compound 16961
                                    polypyrrole 590
                                      tetrapyrrole 478
                                        cyclic tetrapyrrole 347
                                          porphyrins 328
                                            protoporphyrins 315
                                              protoporphyrin 25
                                                hematoporphyrin 0
                                                protoporphyrin monomethyl ester 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.