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Term:dihydrofolic acid
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Accession:CHEBI:15633 term browser browse the term
Definition:A folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis.
Synonyms:related_synonym: 7,8-Dihydrofolate;   7,8-Dihydrofolic acid;   7,8-Dihydropteroylglutamate;   Dihydrofolate;   Formula=C19H21N7O6;   InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1;   InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N;   N-(4-{[(2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid;   N-(7,8-dihydropteroyl)-L-glutamic acid;   SMILES=Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=Nc2c(=O)[nH]1
 alt_id: CHEBI:12245;   CHEBI:14150;   CHEBI:20768;   CHEBI:42000;   CHEBI:4564
 xref: CAS:4033-27-6 "KEGG COMPOUND";   DrugBank:DB02015;   KEGG:C00415;   KNApSAcK:C00007248
 xref_mesh: MESH:C010920
 cyclic_relationship: is_conjugate_acid_of CHEBI:57451

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dihydrofolic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6480464
G Nat1 N-acetyltransferase 1 JBrowse link 16 23,970,742 23,991,573 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,354,517 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        biochemical role 19138
          metabolite 19106
            prokaryotic metabolite 18227
              bacterial metabolite 18227
                Escherichia coli metabolite 18121
                  dihydrofolic acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        amino acid 12315
                                          alpha-amino acid 7422
                                            L-alpha-amino acid 7079
                                              glutamine family amino acid 5338
                                                L-glutamic acid 5240
                                                  L-glutamic acid derivative 3694
                                                    folic acids 3690
                                                      dihydrofolic acids 4
                                                        dihydrofolic acid 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.