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Term:10-formyltetrahydrofolic acid
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Accession:CHEBI:15637 term browser browse the term
Definition:A form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-formyltetrahydrofolic acid is used as a substrate in formyltransferase reactions, which is important in purine biosynthesis.
Synonyms:exact_synonym: N-[4-(N-{[(6S)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)benzoyl]-L-glutamic acid
 related_synonym: (6S)-10-HCO-H4folate;   10-FTHF;   10-Formyl-THF;   10-Formyltetrahydrofolate;   10-formyltetrahydropteroylglutamic acid;   Formula=C20H23N7O7;   InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11-,13+/m1/s1;   InChIKey=AUFGTPPARQZWDO-YPMHNXCESA-N;   N-(10-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   SMILES=[H]C(=O)N(C[C@H]1CNc2nc(N)[nH]c(=O)c2N1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
 alt_id: CHEBI:11304;   CHEBI:19108;   CHEBI:19109;   CHEBI:698
 xref: Beilstein:101559 "Beilstein";   CAS:2800-34-2 "ChemIDplus";   CAS:2800-34-2 "KEGG COMPOUND";   KEGG:C00234;   KNApSAcK:C00007251
 xref_mesh: MESH:C010161
 cyclic_relationship: is_conjugate_acid_of CHEBI:57454

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10-formyltetrahydrofolic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 JBrowse link 7 26,375,866 26,425,838 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        biochemical role 19130
          metabolite 19098
            prokaryotic metabolite 18225
              bacterial metabolite 18225
                Escherichia coli metabolite 18120
                  10-formyltetrahydrofolic acid 1
                    10-formyltetrahydrofolyl polyglutamate macromolecule + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        amino acid 12312
                                          alpha-amino acid 7423
                                            L-alpha-amino acid 7080
                                              glutamine family amino acid 5341
                                                L-glutamic acid 5243
                                                  L-glutamic acid derivative 3697
                                                    folic acids 3693
                                                      tetrahydrofolic acid 63
                                                        formyltetrahydrofolic acid 55
                                                          10-formyltetrahydrofolic acid 1
                                                            10-formyltetrahydrofolyl polyglutamate macromolecule + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.