Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene B4
go back to main search page
Accession:CHEBI:15647 term browser browse the term
Definition:A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.
Synonyms:related_synonym: (5S,12R,6Z,8E,10E,14Z)-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid;   (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoic acid;   (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid;   (S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid;   5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-eicosatetraenoic acid;   5(S),12(R)-dihydroxy-6(Z),8(E),10(E),14(Z)-icosatetraenoic acid;   5,12-Dihete;   5,12-Hete;   5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid;   Formula=C20H32O4;   InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1;   InChIKey=VNYSSYRCGWBHLG-AMOLWHMGSA-N;   LTB4;   SMILES=CCCCC\\C=C/C[C@@H](O)\\C=C\\C=C\\C=C/[C@@H](O)CCCC(O)=O
 alt_id: CHEBI:10933;   CHEBI:25024;   CHEBI:6421
 xref: CAS:71160-24-2 "ChemIDplus";   CAS:71160-24-2 "KEGG COMPOUND";   HMDB:HMDB0001085;   KEGG:C02165;   LIPID_MAPS_instance:LMFA03020001 "LIPID MAPS"
 xref_mesh: MESH:D007975
 xref: PMID:20400503 "Europe PMC";   PMID:20529300 "Europe PMC";   PMID:6271967 "Europe PMC";   Reaxys:4235309 "Reaxys";   Wikipedia:Leukotriene_B4
 cyclic_relationship: is_conjugate_acid_of CHEBI:57461


show annotations for term's descendants       view all columns           Sort by:
 
leukotriene B4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6480464
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 10 69,476,866 69,478,416 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Csf2 colony stimulating factor 2 JBrowse link 10 39,602,089 39,604,070 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 19 37,476,083 37,481,326 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:6480464
G Lta4h leukotriene A4 hydrolase JBrowse link 7 34,288,333 34,320,243 RGD:6480464
G Ltb4r leukotriene B4 receptor JBrowse link 15 34,449,299 34,453,352 RGD:6480464
G Ltb4r2 leukotriene B4 receptor 2 JBrowse link 15 34,446,478 34,448,220 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Sell selectin L JBrowse link 13 82,369,820 82,387,774 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    chemical entity 19667
      atom 19665
        nonmetal atom 19531
          carbon atom 19420
            organic molecular entity 19420
              lipid 16950
                fatty acid 15814
                  long-chain fatty acid 1638
                    leukotriene B4 39
                      10,11-dihydro-12-oxoleukotriene B4 0
                      10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                      10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                      12,20-dioxoleukotriene B4 0
                      12-dehydro-leukotriene B4 0
                      12-oxo-20-hydroxyleukotriene B4 0
                      18-hydroxy-18-oxo-dinorleukotriene B4 0
                      18-hydroxyleukotriene B4 0
                      19-hydroxyleukotriene B4 0
                      20,20,20-trihydroxyleukotriene B4 0
                      20,20-dihydroxyleukotriene B4 0
                      20-hydroxy-20-oxoleukotriene B4 + 0
                      20-hydroxy-leukotriene B4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          fatty acid 15814
                                            unsaturated fatty acid 888
                                              polyunsaturated fatty acid 646
                                                fatty acid 20:4 309
                                                  icosatetraenoic acid 309
                                                    icosa-6,8,10,14-tetraenoic acid 39
                                                      leukotriene B4 39
                                                        10,11-dihydro-12-oxoleukotriene B4 0
                                                        10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                                                        10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                                                        12,20-dioxoleukotriene B4 0
                                                        12-dehydro-leukotriene B4 0
                                                        12-oxo-20-hydroxyleukotriene B4 0
                                                        18-hydroxy-18-oxo-dinorleukotriene B4 0
                                                        18-hydroxyleukotriene B4 0
                                                        19-hydroxyleukotriene B4 0
                                                        20,20,20-trihydroxyleukotriene B4 0
                                                        20,20-dihydroxyleukotriene B4 0
                                                        20-hydroxy-20-oxoleukotriene B4 + 0
                                                        20-hydroxy-leukotriene B4 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.